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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] | ||
| Ligand | BDBM597674 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | RET Enzyme Assay | ||
| IC50 | 4.10±n/a nM | ||
| Citation |  Blake, JF; Dai, D; Haas, J; Jiang, Y; Kolakowski, GR; McFaddin, EA; McKenney, ML; Metcalf, AT; Moreno, DA; Prigaro, B; Ramann, GA; Ren, L Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors US Patent US11603374 Publication Date 3/14/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] | |||
| Name: | Proto-oncogene tyrosine-protein kinase receptor Ret [G810R] | ||
| Synonyms: | CDHF12 | CDHR16 | PTC | Proto-oncogene tyrosine-protein kinase receptor Ret (G810R) | RET | RET Kinase (G810R) | RET kinase mutant (G810R) | RET51 | RET_HUMAN | ret enzyme (g810r) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 124418.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P07949[G810R] | ||
| Residue: | 1114 | ||
| Sequence: |
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| BDBM597674 | |||
| n/a | |||
| Name | BDBM597674 | ||
| Synonyms: | US11603374, Example 29 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H19N5O2 | ||
| Mol. Mass. | 325.3651 | ||
| SMILES | Nc1ncnc2n(cc(-c3cc(on3)C3CC3)c12)[C@H]1C[C@H](CO)C1 |r,wU:18.21,wD:20.24,(-2.78,4.69,;-3.17,3.2,;-4.68,2.88,;-5.16,1.42,;-4.13,.27,;-2.62,.59,;-1.37,-.31,;-.13,.59,;-.6,2.06,;.17,3.39,;1.71,3.39,;2.18,4.85,;.94,5.76,;-.31,4.85,;3.67,5.25,;5.16,4.85,;4.76,6.34,;-2.14,2.06,;-1.37,-1.85,;-.29,-2.94,;-1.37,-4.03,;-1.37,-5.57,;-.04,-6.34,;-2.46,-2.94,)| | ||
| Structure | 
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