| Reaction Details |
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 | Report a problem with these data |
| Target | Envelope glycoprotein gp160 |
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| Ligand | BDBM598794 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HIV MT-4 Serum Shift Antiviral Reporter Assay |
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| EC50 | 1.000±n/a nM |
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| Citation |  Chu, H; Gonzalez Buenrostro, AZ; Guo, H; Han, X; Hurtley, AE; Jiang, L; Li, J; Lin, DW; Mitchell, ML; Naduthambi, D; Schwarzwälder, GM; Szewczyk, SM; Von Bargen, MJ; Wu, Q; Yang, H; Zhang, JR Substituted pyridotriazine compounds and uses thereof US Patent US11613546 Publication Date 3/28/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Envelope glycoprotein gp160 |
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| Name: | Envelope glycoprotein gp160 |
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| Synonyms: | ENV_HV1H2 | Envelope polyprotein GP160 | Envelope surface glycoprotein gp160, precursor | HIV-1 B HXB2-LAI-IIIB-BRU | env |
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| Type: | n/a |
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| Mol. Mass.: | 97241.93 |
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| Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) |
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| Description: | n/a |
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| Residue: | 856 |
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| Sequence: | MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKA
YDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCV
KLTPLCVSLKCTDLKNDTNTNSSSGRMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLD
IIPIDNDTTSYKLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCT
NVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDNAKTIIVQLNTSVEINCTRPN
NNTRKRIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIASKLREQFGNNKTII
FKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRI
KQIINMWQKVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWR
SELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQ
ARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSG
KLICTTAVPWNASWSNKSLEQIWNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQEL
LELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTH
LPTPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTR
IVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAI
RHIPRRIRQGLERILL
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| BDBM598794 |
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| n/a |
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| Name | BDBM598794 |
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| Synonyms: | US11613546, Example C76 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18F4N4O4 |
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| Mol. Mass. | 466.3856 |
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| SMILES | C[C@H]1C=C[C@@H](CF)N2CN1C(=O)c1c(O)c(=O)c(cn21)C(=O)NCc1c(F)cc(F)cc1F |r,c:2| |
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| Structure | 
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