| Reaction Details |
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 | Report a problem with these data |
| Target | Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
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| Ligand | BDBM601200 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human RNR Inhibition Effect |
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| IC50 | 50.0±n/a nM |
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| Citation |  Miyahara, S; Ueno, H; Hara, S; Ogino, Y Sulfonamide compound or salt thereof US Patent US11634395 Publication Date 4/25/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
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| Name: | Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
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| Synonyms: | RRM1/RRM2 holoenzyme | Ribonucleoside-diphosphate reductase M1/M2 chain |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Ribonucleoside-diphosphate reductase large subunit |
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| Synonyms: | RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90074.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_90946 |
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| Residue: | 792 |
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| Sequence: | MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
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| Component 2 |
| Name: | Ribonucleoside-diphosphate reductase subunit M2 |
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| Synonyms: | RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44868.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_195255 |
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| Residue: | 389 |
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| Sequence: | MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
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| BDBM601200 |
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| n/a |
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| Name | BDBM601200 |
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| Synonyms: | 5-fluoro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5- | US11634395, Example 224A | US11634395, Example 224B | US11634395, Example 227A | US11634395, Example 227B |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22BrF2N3O6S |
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| Mol. Mass. | 574.392 |
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| SMILES | C[C@@H]([C@H](NS(=O)(=O)c1ccc(F)c2c1OCCC2(C)O)c1n[nH]c(=O)o1)c1c(F)ccc(Br)c1C |r| |
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| Structure | 
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