| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM9060 |
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| Substrate/Competitor | BDBM8978 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | 2.6±n/a nM |
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| Citation |  Hu, MK; Wu, LJ; Hsiao, G; Yen, MH Homodimeric tacrine congeners as acetylcholinesterase inhibitors. J Med Chem45:2277-82 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
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| Type: | Homotetramer |
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| Mol. Mass.: | 68422.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06276 |
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| Residue: | 602 |
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| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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| BDBM9060 |
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| BDBM8978 |
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| Name | BDBM9060 |
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| Synonyms: | Homodimeric Tacrine Analog 4b | N,N-Bis-(2,3,4,5-tetrahydro-1H-cyclohepta[1,2,-b]quinolin-10-yl)-1,7-diaminoheptane | N-(7-{6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-ylamino}heptyl)-6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C35H44N4 |
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| Mol. Mass. | 520.7507 |
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| SMILES | C(CCCNc1c2CCCCCc2nc2ccccc12)CCCNc1c2CCCCCc2nc2ccccc12 |
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| Structure | 
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