| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM601450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Activity Test of Compounds in the CHK1 Coupled Reaction System |
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| IC50 | <1.000±n/a nM |
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| Citation |  Liao, Y; Qian, W; Wei, C; Xiao, Y; Xi, Z; Zhang, C; Li, J; Chen, S Diazaindole derivative and use thereof as CHK1 inhibitor US Patent US11634424 Publication Date 4/25/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM601450 |
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| n/a |
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| Name | BDBM601450 |
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| Synonyms: | US11634424, Compound 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21F2N7O |
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| Mol. Mass. | 425.4345 |
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| SMILES | COc1cccc(F)c1-c1cc(Nc2cnc3c(F)cn(C4CCNCC4)c3n2)n[nH]1 |
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| Structure | 
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