| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk2 |
|---|
| Ligand | BDBM601450 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Activity Test of Compounds in the CHK1 Coupled Reaction System |
|---|
| IC50 | 2.00±n/a nM |
|---|
| Citation |  Liao, Y; Qian, W; Wei, C; Xiao, Y; Xi, Z; Zhang, C; Li, J; Chen, S Diazaindole derivative and use thereof as CHK1 inhibitor US Patent US11634424 Publication Date 4/25/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Chk2 |
|---|
| Name: | Serine/threonine-protein kinase Chk2 |
|---|
| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60908.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O96017 |
|---|
| Residue: | 543 |
|---|
| Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
|
|
|
|---|
| BDBM601450 |
|---|
| n/a |
|---|
| Name | BDBM601450 |
|---|
| Synonyms: | US11634424, Compound 16 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21F2N7O |
|---|
| Mol. Mass. | 425.4345 |
|---|
| SMILES | COc1cccc(F)c1-c1cc(Nc2cnc3c(F)cn(C4CCNCC4)c3n2)n[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
