| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-1 |
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| Ligand | BDBM603862 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity |
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| IC50 | 3.00±n/a nM |
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| Citation |  Yu, PB; Huang, W; Sanderson, PE; Jiang, J; Shamim, K; Zheng, W; Huang, X; Tawa, G; Lee, A; Alimardanov, A; Huang, J ALK2 inhibitors and methods for inhibiting BMP signaling US Patent US11654147 Publication Date 5/23/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-1 |
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| Name: | Activin receptor type-1 |
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| Synonyms: | 2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I |
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| Type: | n/a |
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| Mol. Mass.: | 57158.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 509 |
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| Sequence: | MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
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| BDBM603862 |
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| n/a |
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| Name | BDBM603862 |
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| Synonyms: | US11654147, Compound 312 | US11654147, Compound 338 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27FN6 |
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| Mol. Mass. | 430.5205 |
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| SMILES | CN1CCN(CC1)C1CN(C1)c1cnc2c(cnn2c1)-c1cc(C)cc2ccc(F)cc12 |
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| Structure | 
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