| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM605999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IP-One assay kit |
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| IC50 | 0.600±n/a nM |
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| Citation |  Bogen, SL; Clausen, DJ; Guiadeen, DG; Hao, J; Lin, S; Rudd, MT; Wei, L; Xiao, L; Yang, D Bicycloheptane pyrrolidine orexin receptor agonists US Patent US11680060 Publication Date 6/20/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM605999 |
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| n/a |
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| Name | BDBM605999 |
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| Synonyms: | US11680060, Example 66 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29F3N4O5S |
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| Mol. Mass. | 506.539 |
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| SMILES | C[C@@H]1C[C@H](NS(C)(=O)=O)[C@H](CO[C@H]2CC[C@]3(C[C@H]3C2)c2ncc(F)cn2)N1C(=O)OCC(F)F |r| |
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| Structure | 
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