Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
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Ligand | BDBM606171 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Selectivity Kinase Assay |
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Ki | 0.120±n/a nM |
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Citation | Barber, J; Cho-Schultz, S; Del Bel, ML; Gallego, RA; He, M; Jalaie, M; Kania, RS; McTigue, MA; Nair, SK; Schmitt, AD; Tuttle, JB; Zhou, D; Zhou, R Azalactam compounds as HPK1 inhibitors US Patent US11684616 Publication Date 6/27/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase kinase 1 |
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Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
Type: | PROTEIN |
Mol. Mass.: | 91316.07 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_586597 |
Residue: | 833 |
Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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BDBM606171 |
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n/a |
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Name | BDBM606171 |
Synonyms: | 4-(2- aminopropan- 2-yl)-2-[6-(5- methyl-4- propyl-4H- 1,2,4-triazol- 3-yl)pyridin-2- yl]-6-[(2R)-2- methylpyrroli- din-1-yl]-2,3- dihydro-1H- pyrrolo[3,4- c]pyridin-1- one | US11684616, Example 133 |
Type | Small organic molecule |
Emp. Form. | C26H34N8O |
Mol. Mass. | 474.6012 |
SMILES | CCCn1c(C)nnc1-c1cccc(n1)N1Cc2c(cc(nc2C(C)(C)N)N2CCC[C@H]2C)C1=O |r| |
Structure |
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