| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin reductase 2 |
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| Ligand | BDBM616845 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PTGR2 Inhibiting Activity Assay |
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| IC50 | 12.0±n/a nM |
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| Citation |  Tsou, LK; Hung, M; Chen, CW; Hsieh, M; Chang, Y; Chuang, LM PTGR2 INHIBITORS AND THEIR USE US Patent US20230279008 Publication Date 9/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin reductase 2 |
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| Name: | Prostaglandin reductase 2 |
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| Synonyms: | 15-oxoprostaglandin 13-reductase | PRG-2 | Zinc-binding alcohol dehydrogenase domain-containing protein 1 |
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| Type: | Protein |
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| Mol. Mass.: | 38492.48 |
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| Organism: | Human |
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| Description: | Q8N8N7 |
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| Residue: | 351 |
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| Sequence: | MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDT
GTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQ
LVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGC
SRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTV
ISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGI
LQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL
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| BDBM616845 |
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| n/a |
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| Name | BDBM616845 |
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| Synonyms: | 5-methyl-6-(4-methylbenzyl)-2-(1-(4-phenylpiperazin-1-yl)ethyl)-[1,2,4]triazolo[1,5-a] pyrimidin-7(4H)-one | US20230279008, Compound 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N6O |
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| Mol. Mass. | 442.556 |
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| SMILES | CC(N1CCN(CC1)c1ccccc1)c1nc2[nH]c(C)c(Cc3ccc(C)cc3)c(=O)n2n1 |
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| Structure | 
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