| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor tyrosine-protein kinase erbB-2 [676-775,'YVMA',776-1255] |
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| Ligand | BDBM638169 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | 67.3±n/a nM |
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| Citation |  Boys, ML; Ellis, BD; Gaudino, JJ; Hicken, EJ; Laird, ER; Lazzara, NC; Newhouse, BJ; Pajk, SP Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors US Patent US11834453 Publication Date 12/5/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor tyrosine-protein kinase erbB-2 [676-775,'YVMA',776-1255] |
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| Name: | Receptor tyrosine-protein kinase erbB-2 [676-775,'YVMA',776-1255] |
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| Synonyms: | ErbB2 insYVMA |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 64508.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04626[676-775,'YVMA',776-1255] |
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| Residue: | 584 |
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| Sequence: | KRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAYVMAGVGSPYVSRLLGICLT
STVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNV
LVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVT
VWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRE
LVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFF
CPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLG
MGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPS
PREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPP
AFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
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| BDBM638169 |
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| n/a |
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| Name | BDBM638169 |
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| Synonyms: | US11834453, Example 272 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28N8O2 |
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| Mol. Mass. | 496.5636 |
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| SMILES | Cc1cc(Nc2ncnc3cnc(nc23)N2CCOC(C)(C)C2)ccc1Oc1ccc2n(C)cnc2c1 |
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| Structure | 
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