| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Voltage-dependent calcium channel gamma-2 subunit |
|---|
| Ligand | BDBM311799 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Calcium Flux Assay |
|---|
| IC50 | 0.126±n/a nM |
|---|
| Citation |  Ameriks, MK; Laforteza, BN; Lebold, TP; Ravula, S; Savall, BM; Shireman, BT Fused azaheterocyclic compounds and their use as AMPA receptor modulators US Patent US10155769 Publication Date 12/18/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Voltage-dependent calcium channel gamma-2 subunit |
|---|
| Name: | Voltage-dependent calcium channel gamma-2 subunit |
|---|
| Synonyms: | CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 35977.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 323 |
|---|
| Sequence: | MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTH
SGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGL
CIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSF
YFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSS
SRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVH
NCIQKENKDSLHSNTANRRTTPV
|
|
|
|---|
| BDBM311799 |
|---|
| n/a |
|---|
| Name | BDBM311799 |
|---|
| Synonyms: | 8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridine | US10155769, Example 37 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H13ClF3N5 |
|---|
| Mol. Mass. | 379.767 |
|---|
| SMILES | CC(C)c1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(ccn2n1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
