Reaction Details |
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Target | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238] |
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Ligand | BDBM646474 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Enzymatic Activity Assay on WRN Helicase |
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IC50 | 60.0±n/a nM |
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Citation | Bordas, V; Brun, J; Furegati, M; Hamon, J; Hinrichs, JH; Holzer, P; Limam, F; Möbitz, H; Nocito, S; Plattner, S; Schmiedeberg, N; Schoepfer, J; Strang, RS; Zecri, F Bicyclic compounds and their uses US Patent US11878973 Publication Date 1/23/2024 |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238] |
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Name: | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238] |
Synonyms: | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (517-1238) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 81717.91 |
Organism: | Homo sapiens (Human) |
Description: | Q14191[517-1238] |
Residue: | 722 |
Sequence: | NEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYG
KSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKY
RIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPM
VPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVK
TSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQ
CVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLN
RHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCC
DNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLAD
QYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANT
ESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCD
KISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPA
ILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSST
KP
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BDBM646474 |
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n/a |
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Name | BDBM646474 |
Synonyms: | US11878973, Example 58 |
Type | Small organic molecule |
Emp. Form. | C32H33F3N8O5 |
Mol. Mass. | 666.6502 |
SMILES | CCc1c(N2CCN(CC2)C(=O)c2ncccc2O)c(=O)n2nc(nc2n1CC(=O)Nc1ccc(cc1C)C(F)(F)F)C1=CCOCC1 |t:47| |
Structure |
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