| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM647751 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RIPK1-ADP-Glo Enzymatic Assay |
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| EC50 | 44.0±n/a nM |
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| Citation |  Chen, JL; Chen, Y; DiMauro, EF; Liu, M; Methot, JL; Musacchio, AJ; Palani, A; Pio, B; Duque, LR; Siliphaivanh, P; Vara, BA RIPK1 INHIBITORS AND METHODS OF USE US Patent US20240025912 Publication Date 1/25/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 75926.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13546 |
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| Residue: | 671 |
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| Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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| BDBM647751 |
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| n/a |
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| Name | BDBM647751 |
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| Synonyms: | (S)-3-(5-(4-chlorophenyl)-3-oxo-6,7- dihydro-3H-pyrrolo[2,1- c][1,2,4]triazol-2(5H)- yl)bicyclo[1.1.1]pentane-1-carbonitrile | US20240025912, Compound 1-46 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15ClN4O |
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| Mol. Mass. | 326.78 |
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| SMILES | Clc1ccc(cc1)[C@@H]1CCc2nn(c(=O)n12)C12CC(C1)(C2)C#N |r| |
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| Structure | 
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