| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-1 |
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| Ligand | BDBM655581 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Steroid Inhibition of TBPS Binding |
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| IC50 | 30±n/a nM |
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| Citation |  Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT 19-nor neuroactive steroids and methods of use thereof US Patent US11912737 Publication Date 2/27/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit alpha-1 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-1 |
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| Synonyms: | Benzodiazepine central | Benzodiazepine receptors | GABA A Benzodiazepine | GABA A Benzodiazepine Type I | GABA A Benzodiazepine Type II | GABA A Benzodiazepine Type IIL | GABA A Benzodiazepine Type IIM | GABA A Benzodiazepine omega1 | GABA A Benzodiazepine omega2 | GABA A Benzodiazepine omega5 | GABA A alpha1 | GABA A anti-Alpha1 | GABA receptor alpha-1 subunit | GABA, Chloride, TBOB | GABA-PICROTOXIN | GBRA1_RAT | Gabra-1 | Gabra1 | TBPS |
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| Type: | Enzyme |
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| Mol. Mass.: | 51770.21 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P62813 |
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| Residue: | 455 |
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| Sequence: | MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGL
GERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKI
WTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACP
LKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMT
THFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISAR
NSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPL
IKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDR
LSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
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| BDBM655581 |
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| n/a |
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| Name | BDBM655581 |
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| Synonyms: | US11912737, Example 31. |
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| Type | Small organic molecule |
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| Emp. Form. | C27H45NO3 |
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| Mol. Mass. | 431.6511 |
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| SMILES | C[C@H]1CN(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)C[C@H](C)O1 |r| |
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| Structure | 
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