| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
|---|
| Ligand | BDBM179834 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radioligand Binding Assay |
|---|
| pH | 6±n/a |
|---|
| Ki | 2.10±n/a nM |
|---|
| IC50 | 5.70±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Barrett, SD; Germain, BD; Uzieblo, A; Ciske, FL; Endres, GW; Kornilov, A; Maxey, KM; O'Malley, JP; Owen, TA Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions US Patent US9676712 Publication Date 6/13/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin E2 receptor EP4 subtype |
|---|
| Name: | Prostaglandin E2 receptor EP4 subtype |
|---|
| Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53134.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35408 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
|
|
|
|---|
| BDBM179834 |
|---|
| n/a |
|---|
| Name | BDBM179834 |
|---|
| Synonyms: | US9676712, 2C |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H37NO4 |
|---|
| Mol. Mass. | 415.5656 |
|---|
| SMILES | CC(CCCc1ccccc1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
