| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [808-1132] |
|---|
| Ligand | BDBM264225 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Inhibition Studies |
|---|
| IC50 | 790±n/a nM |
|---|
| Citation |  Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent US10167276 Publication Date 1/1/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK2 [808-1132] |
|---|
| Name: | Tyrosine-protein kinase JAK2 [808-1132] |
|---|
| Synonyms: | JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39171.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60674[808-1132] |
|---|
| Residue: | 335 |
|---|
| Sequence: | FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGK
GNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL
ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDE
IYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
|
|
|
|---|
| BDBM264225 |
|---|
| n/a |
|---|
| Name | BDBM264225 |
|---|
| Synonyms: | (2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide | US10167276, Example 45 | US10654835, Example 45 | US11247983, Example 45 | US9714236, 45 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H35N9O3 |
|---|
| Mol. Mass. | 533.6253 |
|---|
| SMILES | COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
