| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Ligand | BDBM313643 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Raf Activity Determination |
|---|
| IC50 | 30.0±n/a nM |
|---|
| Citation |  Aversa, RJ; Burger, MT; Dillon, MP; Dineen, Jr., TA; Lou, Y; Nishiguchi, GA; Ramurthy, S; Rico, AC; Rauniyar, V; Sendzik, M; Subramanian, S; Setti, LQ; Taft, BR; Tanner, HR; Wan, L Compounds and compositions as RAF kinase inhibitors US Patent US10167279 Publication Date 1/1/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Name: | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 73082.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04049 |
|---|
| Residue: | 648 |
|---|
| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
|
|
|
|---|
| BDBM313643 |
|---|
| n/a |
|---|
| Name | BDBM313643 |
|---|
| Synonyms: | 2-(1,1-difluoroethyl)-N- (3-(2-(2- hydroxyethoxy)-6- (tetrahydro-2H-pyran-4- yl)pyridin-4-yl)-4- methylphenyl) isonicotinamide | US10167279, Example 269 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H29F2N3O4 |
|---|
| Mol. Mass. | 497.5337 |
|---|
| SMILES | Cc1ccc(NC(=O)c2ccnc(c2)C(C)(F)F)cc1-c1cc(OCCO)nc(c1)C1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
