| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldehyde dehydrogenase, mitochondrial |
|---|
| Ligand | BDBM153696 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ALDH2 Assay |
|---|
| IC50 | 25.0±n/a nM |
|---|
| Citation |  Cannizzaro, CE; Graupe, M; Guerrero, JA; Lu, Y; Strickley, RG; Venkataramani, C; Zablocki, J Compounds for the treatment of addiction US Patent US9610299 Publication Date 4/4/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldehyde dehydrogenase, mitochondrial |
|---|
| Name: | Aldehyde dehydrogenase, mitochondrial |
|---|
| Synonyms: | ALDH class 2 | ALDH-E2 | ALDH2 | ALDH2_HUMAN | ALDHI | ALDM | Aldehyde dehydrogenase (ALDH2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56382.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05091 |
|---|
| Residue: | 517 |
|---|
| Sequence: | MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
|
|
|
|---|
| BDBM153696 |
|---|
| n/a |
|---|
| Name | BDBM153696 |
|---|
| Synonyms: | US10507215, Compound 13 | US9000015, 13 | US9610299, Example 13 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H13Cl2FN2O2 |
|---|
| Mol. Mass. | 391.223 |
|---|
| SMILES | Fc1c[nH]c(=O)cc1-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
