| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM10675 |
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| Substrate/Competitor | Caspase Fluorogenic Substrate |
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| Meas. Tech. | Caspase Inhibition Assay |
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| pH | 7±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 1.8±n/a nM |
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| Citation |  Han, Y; Giroux, A; Grimm, EL; Aspiotis, R; Francoeur, S; Bayly, CI; Mckay, DJ; Roy, S; Xanthoudakis, S; Vaillancourt, JP; Rasper, DM; Tam, J; Tawa, P; Thornberry, NA; Paterson, EP; Garcia-Calvo, M; Becker, JW; Rotonda, J; Nicholson, DW; Zamboni, RJ Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors. Bioorg Med Chem Lett14:805-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM10675 |
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| Caspase Fluorogenic Substrate |
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| Name: | Caspase Fluorogenic Substrate |
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| Synonyms: | Ac-DEVD-AMC | Caspase Fluorogenic Substrate |
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| Type: | Peptide |
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| Mol. Mass.: | 1461.77 |
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| Organism: | n/a |
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| Description: | AMC=7-Amino-4-methylcoumarin |
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| Residue: | 16 |
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| Sequence: | |
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