| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 21-hydroxylase |
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| Ligand | BDBM25458 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Activity Assay |
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| IC50 | 296±26 nM |
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| Citation |  Aube, J; Scott, EE; Fehl, C Inhibitors of CYP17A1 US Patent US9611270 Publication Date 4/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid 21-hydroxylase |
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| Name: | Steroid 21-hydroxylase |
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| Synonyms: | CP21A_HUMAN | CYP21 | CYP21A2 | CYP21B | Cytochrome P450 21 | Cytochrome P450 21A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55896.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1498865 |
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| Residue: | 494 |
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| Sequence: | MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAHK
KLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDK
IKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQ
LRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTL
SWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVP
LALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRL
QPRGMGAHSPGQNQ
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| BDBM25458 |
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| n/a |
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| Name | BDBM25458 |
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| Synonyms: | (1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-(pyridin-3-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-7,13-dien-5-ol | ABT | Abiraterone | CB 7598 | CHEMBL254328 | US9487554, Abiraterone | US9611270, Example 5, abiraterone |
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| Type | steroidal compound |
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| Emp. Form. | C24H31NO |
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| Mol. Mass. | 349.509 |
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| SMILES | [H][C@@]12CC=C(c3cccnc3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C |t:3,23| |
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| Structure | 
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