| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Steroid 21-hydroxylase |
|---|
| Ligand | BDBM314740 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Activity Assay |
|---|
| IC50 | 8.00±912 nM |
|---|
| Citation |  Aube, J; Scott, EE; Fehl, C Inhibitors of CYP17A1 US Patent US9611270 Publication Date 4/4/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Steroid 21-hydroxylase |
|---|
| Name: | Steroid 21-hydroxylase |
|---|
| Synonyms: | CP21A_HUMAN | CYP21 | CYP21A2 | CYP21B | Cytochrome P450 21 | Cytochrome P450 21A2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55896.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1498865 |
|---|
| Residue: | 494 |
|---|
| Sequence: | MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAHK
KLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDK
IKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQ
LRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTL
SWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVP
LALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRL
QPRGMGAHSPGQNQ
|
|
|
|---|
| BDBM314740 |
|---|
| n/a |
|---|
| Name | BDBM314740 |
|---|
| Synonyms: | US9611270, Example 42 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H32N2O2 |
|---|
| Mol. Mass. | 392.5338 |
|---|
| SMILES | C[C@]12CC[C@H]3[C@@H](CC(C(N)=O)=C4C[C@@H](O)CC[C@]34C)[C@@H]1CC=C2c1cccnc1 |r,c:24,t:10| |
|---|
| Structure | 
|
|---|
Search and Browse
