| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1A adrenergic receptor |
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| Ligand | BDBM317607 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 14.0±n/a nM |
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| Citation |  Becker-Pelster, EM; Buchgraber, P; Buchmüller, A; Engel, K; Göller, A; Himmel, H; Kast, R; Keldenich, J; Schmeck, C; Tinel, H; Wunder, F Substituted bipiperidinyl derivatives US Patent US9624199 Publication Date 4/18/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1A adrenergic receptor |
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| Name: | Alpha-1A adrenergic receptor |
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| Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 51511.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35348 |
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| Residue: | 466 |
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| Sequence: | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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| BDBM317607 |
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| n/a |
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| Name | BDBM317607 |
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| Synonyms: | US9624199, 17 | [3-(Cyclopropylmethoxy)-1,4′-bipiperidin-1′-yl][2-(morpholin-4-yl)pyrimidin-5-yl]methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C23H35N5O3 |
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| Mol. Mass. | 429.5557 |
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| SMILES | O=C(N1CCC(CC1)N1CCCC(C1)OCC1CC1)c1cnc(nc1)N1CCOCC1 |
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| Structure | 
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