| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM319614 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | 5-HT2A Receptor Antagonism Activity Test |
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| IC50 | 6.36±n/a nM |
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| Citation |  Jiang, H; Wang, Z; Li, J; Zhang, R; He, Y; Liu, Y; Bi, M; Liu, Z; Tian, G; Chen, W; Yang, F; Wu, C; Wang, Y; Jiang, X; Yin, J; Wang, G; Shen, J Heterocyclic compounds, process for preparation of the same and use thereof US Patent US10174011 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A |
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| Type: | undefined |
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| Mol. Mass.: | 52607.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28223 |
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| Residue: | 471 |
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| Sequence: | MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
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| BDBM319614 |
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| n/a |
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| Name | BDBM319614 |
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| Synonyms: | 5-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)indolin-2-one | US10174011, Example 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N3OS |
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| Mol. Mass. | 377.503 |
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| SMILES | O=C1Cc2cc(CCN3CCN(CC3)c3cccc4sccc34)ccc2N1 |
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| Structure | 
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