Reaction Details | |||
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Target | Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform | ||
Ligand | BDBM188328 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | PI3K (p110β/p85α) (h) [Non-Radioactive Assay] | ||
Temperature | 298.15±n/a K | ||
IC50 | >3000±n/a nM | ||
Comments | extracted | ||
Citation | Xi, N; Wang, L; Wu, Z; Feng, X; Wu, Y Substituted aminopyrimidine compounds and methods of use US Patent US9670194 Publication Date 6/6/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform | |||
Name: | Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform | ||
Synonyms: | PI3-kinase subunit p110 beta/p85 alpha | PI3K p110 beta/p85 alpha | PI3K p110beta/p85alpha (Human) | Phosphoinositide 3-Kinase (PI3K), beta | p110β/p85α | p110beta/p85alpha | ||
Type: | Protein | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | ||
Synonyms: | PI3-kinase p110 subunit beta | PI3-kinase subunit p110-beta | PI3Kbeta | PIK3C1 | PIK3CB | PK3CB_HUMAN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta (PI3Kbeta) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3K beta) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3K-beta) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3Kbeta) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3Kÿ²) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Phosphoinositide 3-Kinase (PI3K), beta | Phosphoinositide 3-Kinase (PI3K), beta Chain A | Phosphoinositide-3-kinase (PI3K beta) | PtdIns-3-kinase p110 | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 122769.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P42338 | ||
Residue: | 1070 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Phosphatidylinositol 3-kinase regulatory subunit alpha | ||
Synonyms: | GRB1 | P85A_HUMAN | PI3-kinase class I | PI3-kinase p85 subunit alpha | PI3-kinase p85-alpha subunit | PI3-kinase p85-subunit alpha | PI3-kinase subunit p85-alpha | PI3K | PIK3CG/PIK3R1 | PIK3R1 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha (PI3K alpha) | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3K p85-alpha) | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3RI) | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 (PI3 Kinase alpha) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3Kalpha p85alpha) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3Kalpha) | Phosphoinositide 3-Kinase (PI3K) Chain B | PtdIns-3-kinase p85-alpha | p84 alpha | p85 alpha | ||
Type: | Protein | ||
Mol. Mass.: | 83592.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P27986 | ||
Residue: | 724 | ||
Sequence: |
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BDBM188328 | |||
n/a | |||
Name | BDBM188328 | ||
Synonyms: | US9670194, Ex. 10 2-((1S)-1-((6-amino-5-(1-methyl-1H-1,2,4-triazol-5-yl)pyrimidin-4-yl)amino)propyl)-5-chloro-3-phenylquinazolin-4(3H)-one | ||
Type | Small organic molecule | ||
Emp. Form. | C24H22ClN9O | ||
Mol. Mass. | 487.944 | ||
SMILES | CC[C@H](Nc1ncnc(N)c1-c1ncnn1C)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r,wD:2.2,(4,.62,;2.67,1.39,;1.33,.62,;1.33,-.92,;2.67,-1.69,;4,-.92,;5.33,-1.69,;5.33,-3.23,;4,-4,;4,-5.54,;2.67,-3.23,;1.33,-4,;1.33,-5.54,;-.13,-6.01,;-1.04,-4.77,;-.13,-3.52,;-.9,-2.19,;,1.39,;-1.33,.62,;-2.67,1.39,;-4,.62,;-5.33,1.39,;-5.33,2.93,;-4,3.7,;-4,5.24,;-2.67,2.93,;-1.33,3.7,;-1.33,5.24,;,2.93,;1.33,3.7,;2.67,2.93,;4,3.7,;4,5.24,;2.67,6.01,;1.33,5.24,)| | ||
Structure |