| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf [416-766,V600E] |
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| Ligand | BDBM322528 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LanthaScreen Eu kinase binding assay |
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| IC50 | <4±n/a nM |
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| Citation |  Bingham, M; Testar, R; Gignoux, C Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers US Patent US10183939 Publication Date 1/22/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Serine/threonine-protein kinase B-raf [416-766,V600E] |
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| Name: | Serine/threonine-protein kinase B-raf [416-766,V600E] |
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| Synonyms: | B-Raf (V600E) | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 |
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| Type: | n/a |
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| Mol. Mass.: | 39690.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PV3849, from Invitrogen |
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| Residue: | 351 |
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| Sequence: | LQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGK
WHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGS
SLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDF
GLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP
YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE
LLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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| BDBM322528 |
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| n/a |
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| Name | BDBM322528 |
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| Synonyms: | 5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]oxy-3,4-dihydro-1H-1,8-naphthyridin-2-one | US10183939, Example 6 | USRE49361, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20N4O3S |
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| Mol. Mass. | 444.506 |
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| SMILES | O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccsc3)ccnc2N1 |
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| Structure | 
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