Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Wnt-3a (Mus musculus) | BDBM346247 (2-[2-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346240 (2-[5-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346260 (2-[4-(2-methyl-4-pyridyl)pyrrolo[3,2-c]pyridin-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322529 (5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM322529 (5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346238 (2-[5-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo... | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346268 (2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-b]pyridin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346238 (2-[5-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346268 (2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-b]pyridin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346240 (2-[5-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346262 (2-[4-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346261 (2-[4-(2-methyl-4-pyridyl)pyrrolo[2,3-c]pyridin-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346244 (2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-c]pyridin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346258 (N-(5-pyrazin-2-yl-2-pyridyl)-2-[4-[2-(trifluoromet...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346249 (2-[2-chloro-4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346248 (2-[4-(2-methylpyrazol-3-yl)pyrazolo[3,4-d]pyrimidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346247 (2-[2-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346239 (2-[5-fluoro-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346245 (2-[2-amino-4-(2-methyl-4-pyridyl)pyrrolo[2,3-d]pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346242 (2-[5-(2-methyl-4-pyridyl)pyrrolo[2,3-b]pyridin-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346240 (2-[5-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346239 (2-[5-fluoro-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346238 (2-[5-methyl-4-(2-methyl-4-pyridyl)pyrrolo[2,3-b]py...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human)) | BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo... | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM322528 (5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346260 (2-[4-(2-methyl-4-pyridyl)pyrrolo[3,2-c]pyridin-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human)) | BDBM322529 (5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo... | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM322529 (5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo... | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo... | US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM322521 (5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))... | Citation and Details BindingDB Entry DOI: 10.7270/Q2J10718 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346267 (2-[4-(1-piperidyl)pyrrolo[2,3-b]pyridin-1-yl]-N-(5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346251 (2-[4-(2-methyl-4-pyridyl)pyrazolo[3,4-d]pyrimidin-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346252 (2-[4-(2-methyl-4-pyridyl)pyrazolo[3,4-b]pyridin-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346241 (2-[4-(2-methylpyrazol-3-yl)pyrrolo[3,2-c]pyridin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346242 (2-[5-(2-methyl-4-pyridyl)pyrrolo[2,3-b]pyridin-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346255 (2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-d]pyrimidin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346257 (2-[4-(2-methyl-4-pyridyl)imidazo[4,5-c]pyridin-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Wnt-3a (Mus musculus) | BDBM346244 (2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-c]pyridin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Mouse L cells transfected to constitutively produce biologically active murine Wnt-3a, referred to as L-Wnt cells, were purchased from the American T... | US Patent US10202375 (2019) BindingDB Entry DOI: 10.7270/Q29W0HMN | |||||||||||
More data for this Ligand-Target Pair |
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