| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 4 |
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| Ligand | BDBM325579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-Based Assay |
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| EC50 | 6.80±n/a nM |
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| Citation |  Nirogi, R; Mohammed, AR; Yarlagadda, S; Ravella, SR; Shinde, AK; Kambhampati, R; Roayapalley, PK; Jayarajan, P; Bhyrapuneni, G; Patnala, SM; Ravula, J; Jasti, V Heteroaryl compounds as 5-HT4 receptor ligands US Patent US9636335 Publication Date 5/2/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 4 |
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| Name: | 5-hydroxytryptamine receptor 4 |
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| Synonyms: | 5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43767.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13639 |
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| Residue: | 388 |
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| Sequence: | MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
AVECGGQWESQCHPPATSPLVAAQPSDT
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| BDBM325579 |
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| n/a |
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| Name | BDBM325579 |
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| Synonyms: | 4-[5-(5-Amino-6-chloro-chroman-8-yl)-[1,3,4]oxadiazol-2-yl]-[1,4′]bipiperidinyl-1′-carboxylic acid ethyl ester | US9636335, 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32ClN5O4 |
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| Mol. Mass. | 489.995 |
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| SMILES | CCOC(=O)N1CCC(CC1)N1CCC(CC1)c1nnc(o1)-c1cc(Cl)c(N)c2CCCOc12 |
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| Structure | 
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