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Compile Data Set for Download or QSAR

Found 44 hits with Last Name = 'yarlagadda' and Initial = 's'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325587
PNG
(5-Chloro-7-[5-(1-cyclopropyl-piperidin-4-yl)-[1,3,...)
Show SMILES Nc1c2CCOc2c(cc1Cl)-c1nnc(o1)C1CCN(CC1)C1CC1
Show InChI InChI=1S/C18H21ClN4O2/c19-14-9-13(16-12(15(14)20)5-8-24-16)18-22-21-17(25-18)10-3-6-23(7-4-10)11-1-2-11/h9-11H,1-8,20H2
PDB

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n/an/an/an/a 60n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325601
PNG
(3-[5-(1-Cyclopentyl-piperidin-4-yl)-[1,3,4]oxadiaz...)
Show SMILES CC(C)n1nc(-c2nnc(o2)C2CCN(CC2)C2CCCC2)c2ccccc12
Show InChI InChI=1S/C22H29N5O/c1-15(2)27-19-10-6-5-9-18(19)20(25-27)22-24-23-21(28-22)16-11-13-26(14-12-16)17-7-3-4-8-17/h5-6,9-10,15-17H,3-4,7-8,11-14H2,1-2H3
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n/an/an/an/a 72n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325589
PNG
(6-Chloro-8-[5-(1-cyclopropyl-piperidin-4-yl)-[1,3,...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC2)C2CC2)c2OCCOc12
Show InChI InChI=1S/C18H21ClN4O3/c19-13-9-12(15-16(14(13)20)25-8-7-24-15)18-22-21-17(26-18)10-3-5-23(6-4-10)11-1-2-11/h9-11H,1-8,20H2
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n/an/an/an/a 21.5n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325590
PNG
(6-Chloro-8-{5-[1-(tetrahydro-pyran-4-yl)-piperidin...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC2)C2CCOCC2)c2OCCOc12
Show InChI InChI=1S/C20H25ClN4O4/c21-15-11-14(17-18(16(15)22)28-10-9-27-17)20-24-23-19(29-20)12-1-5-25(6-2-12)13-3-7-26-8-4-13/h11-13H,1-10,22H2
PDB

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n/an/an/an/a 7.30n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325591
PNG
(6-Chloro-8-{5-[1-(3-methoxy-propyl)-piperidin-4-yl...)
Show SMILES COCCCN1CCC(CC1)c1nnc(o1)-c1cc(Cl)c(N)c2OCCOc12
Show InChI InChI=1S/C19H25ClN4O4/c1-25-8-2-5-24-6-3-12(4-7-24)18-22-23-19(28-18)13-11-14(20)15(21)17-16(13)26-9-10-27-17/h11-12H,2-10,21H2,1H3
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n/an/an/an/a 16.9n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325592
PNG
(5-Chloro-7-{5-[1-(tetrahydro-pyran-4-ylmethyl)-pip...)
Show SMILES Nc1c2CCOc2c(cc1Cl)-c1nnc(o1)C1CCN(CC2CCOCC2)CC1
Show InChI InChI=1S/C21H27ClN4O3/c22-17-11-16(19-15(18(17)23)5-10-28-19)21-25-24-20(29-21)14-1-6-26(7-2-14)12-13-3-8-27-9-4-13/h11,13-14H,1-10,12,23H2
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n/an/an/an/a 21n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325594
PNG
(3-[5-(1-Cyclobutylmethyl-piperidin-4-yl)-[1,3,4]ox...)
Show SMILES CC(C)n1nc(-c2nnc(o2)C2CCN(CC3CCC3)CC2)c2ccccc12
Show InChI InChI=1S/C22H29N5O/c1-15(2)27-19-9-4-3-8-18(19)20(25-27)22-24-23-21(28-22)17-10-12-26(13-11-17)14-16-6-5-7-16/h3-4,8-9,15-17H,5-7,10-14H2,1-2H3
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n/an/an/an/a 169n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325595
PNG
(1-Isopropyl-3-{5-[1-(2-methoxy-ethyl)-piperidin-4-...)
Show SMILES COCCN1CCC(CC1)c1nnc(o1)-c1nn(C(C)C)c2ccccc12
Show InChI InChI=1S/C20H27N5O2/c1-14(2)25-17-7-5-4-6-16(17)18(23-25)20-22-21-19(27-20)15-8-10-24(11-9-15)12-13-26-3/h4-7,14-15H,8-13H2,1-3H3
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n/an/an/an/a 143n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325596
PNG
(3-[5-(1-Cyclobutyl-piperidin-4-yl)-[1,3,4]oxadiazo...)
Show SMILES CC(C)n1nc(-c2nnc(o2)C2CCN(CC2)C2CCC2)c2ccccc12
Show InChI InChI=1S/C21H27N5O/c1-14(2)26-18-9-4-3-8-17(18)19(24-26)21-23-22-20(27-21)15-10-12-25(13-11-15)16-6-5-7-16/h3-4,8-9,14-16H,5-7,10-13H2,1-2H3
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n/an/an/an/a 127n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325597
PNG
(1-Isopropyl-3-[5-(1-isopropyl-piperidin-4-yl)-[1,3...)
Show SMILES CC(C)N1CCC(CC1)c1nnc(o1)-c1nn(C(C)C)c2ccccc12
Show InChI InChI=1S/C20H27N5O/c1-13(2)24-11-9-15(10-12-24)19-21-22-20(26-19)18-16-7-5-6-8-17(16)25(23-18)14(3)4/h5-8,13-15H,9-12H2,1-4H3
PDB

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n/an/an/an/a 23n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325598
PNG
(3-[5-(1-Cyclopropylmethyl-piperidin-4-yl)-[1,3,4]o...)
Show SMILES CC(C)n1nc(-c2nnc(o2)C2CCN(CC3CC3)CC2)c2ccccc12
Show InChI InChI=1S/C21H27N5O/c1-14(2)26-18-6-4-3-5-17(18)19(24-26)21-23-22-20(27-21)16-9-11-25(12-10-16)13-15-7-8-15/h3-6,14-16H,7-13H2,1-2H3
PDB

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n/an/an/an/a 66n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325599
PNG
(1-Isopropyl-3-{5-[1-(3-methyl-butyl)-piperidin-4-y...)
Show SMILES CC(C)CCN1CCC(CC1)c1nnc(o1)-c1nn(C(C)C)c2ccccc12
Show InChI InChI=1S/C22H31N5O/c1-15(2)9-12-26-13-10-17(11-14-26)21-23-24-22(28-21)20-18-7-5-6-8-19(18)27(25-20)16(3)4/h5-8,15-17H,9-14H2,1-4H3
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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325600
PNG
(3-[5-(1-Cyclopropyl-piperidin-4-yl)-[1,3,4]oxadiaz...)
Show SMILES CC(C)n1nc(-c2nnc(o2)C2CCN(CC2)C2CC2)c2ccccc12
Show InChI InChI=1S/C20H25N5O/c1-13(2)25-17-6-4-3-5-16(17)18(23-25)20-22-21-19(26-20)14-9-11-24(12-10-14)15-7-8-15/h3-6,13-15H,7-12H2,1-2H3
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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325602
PNG
(1-Isopropyl-3-{5-[1-(tetrahydro-pyran-4-ylmethyl)-...)
Show SMILES CC(C)n1nc(-c2nnc(o2)C2CCN(CC3CCOCC3)CC2)c2ccccc12
Show InChI InChI=1S/C23H31N5O2/c1-16(2)28-20-6-4-3-5-19(20)21(26-28)23-25-24-22(30-23)18-7-11-27(12-8-18)15-17-9-13-29-14-10-17/h3-6,16-18H,7-15H2,1-2H3
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n/an/an/an/a 84.5n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325603
PNG
(1-Isopropyl-3-{5-[1-(tetrahydro-pyran-4-yl)-piperi...)
Show SMILES CC(C)n1nc(-c2nnc(o2)C2CCN(CC2)C2CCOCC2)c2ccccc12
Show InChI InChI=1S/C22H29N5O2/c1-15(2)27-19-6-4-3-5-18(19)20(25-27)22-24-23-21(29-22)16-7-11-26(12-8-16)17-9-13-28-14-10-17/h3-6,15-17H,7-14H2,1-2H3
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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325604
PNG
(1-Isopropyl-3-[5-(2-piperidin-1-yl-ethyl)-[1,3,4]o...)
Show SMILES CC(C)n1nc(-c2nnc(CCN3CCCCC3)o2)c2ccccc12
Show InChI InChI=1S/C19H25N5O/c1-14(2)24-16-9-5-4-8-15(16)18(22-24)19-21-20-17(25-19)10-13-23-11-6-3-7-12-23/h4-5,8-9,14H,3,6-7,10-13H2,1-2H3
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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325557
PNG
(6-chloro-8-[5-(1-cyclopropyl piperidin-4-yl)-[1,3,...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC2)C2CC2)c2OCCCc12
Show InChI InChI=1S/C19H23ClN4O2/c20-15-10-14(17-13(16(15)21)2-1-9-25-17)19-23-22-18(26-19)11-5-7-24(8-6-11)12-3-4-12/h10-12H,1-9,21H2
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n/an/an/an/a 28.5n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325559
PNG
(6-Chloro-8-[5-(1-cyclobutyl piperidin-4-ylmethyl)-...)
Show SMILES Nc1c(Cl)cc(-c2nnc(CC3CCN(CC3)C3CCC3)o2)c2OCCCc12
Show InChI InChI=1S/C21H27ClN4O2/c22-17-12-16(20-15(19(17)23)5-2-10-27-20)21-25-24-18(28-21)11-13-6-8-26(9-7-13)14-3-1-4-14/h12-14H,1-11,23H2
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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325559
PNG
(6-Chloro-8-[5-(1-cyclobutyl piperidin-4-ylmethyl)-...)
Show SMILES Nc1c(Cl)cc(-c2nnc(CC3CCN(CC3)C3CCC3)o2)c2OCCCc12
Show InChI InChI=1S/C21H27ClN4O2/c22-17-12-16(20-15(19(17)23)5-2-10-27-20)21-25-24-18(28-21)11-13-6-8-26(9-7-13)14-3-1-4-14/h12-14H,1-11,23H2
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n/an/an/an/a 27.5n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325561
PNG
(1-Isopropyl-3-{5-[1-(3-methoxy propyl) piperidin-4...)
Show SMILES COCCCN1CCC(CC1)c1nnc(o1)-c1nn(C(C)C)c2ccccc12
Show InChI InChI=1S/C21H29N5O2/c1-15(2)26-18-8-5-4-7-17(18)19(24-26)21-23-22-20(28-21)16-9-12-25(13-10-16)11-6-14-27-3/h4-5,7-8,15-16H,6,9-14H2,1-3H3
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n/an/an/an/a 38n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325563
PNG
(3-[5-(1-Cyclobutyl-piperidin-4-yl methyl)-[1,3,4]o...)
Show SMILES CC(C)n1nc(-c2nnc(CC3CCN(CC3)C3CCC3)o2)c2ccccc12
Show InChI InChI=1S/C22H29N5O/c1-15(2)27-19-9-4-3-8-18(19)21(25-27)22-24-23-20(28-22)14-16-10-12-26(13-11-16)17-6-5-7-17/h3-4,8-9,15-17H,5-7,10-14H2,1-2H3
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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325564
PNG
(6-Chloro-8-[5-(3-cyclobutyl-3-aza bicyclo[3.1.0]he...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2C3CN(CC23)C2CCC2)c2OCCCc12
Show InChI InChI=1S/C20H23ClN4O2/c21-15-7-12(18-11(17(15)22)5-2-6-26-18)19-23-24-20(27-19)16-13-8-25(9-14(13)16)10-3-1-4-10/h7,10,13-14,16H,1-6,8-9,22H2
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SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325565
PNG
(5-Chloro-7-{5-[1-(tetrahydro pyran-4-yl) piperidin...)
Show SMILES Nc1c2CCOc2c(cc1Cl)-c1nnc(o1)C1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C20H25ClN4O3/c21-16-11-15(18-14(17(16)22)5-10-27-18)20-24-23-19(28-20)12-1-6-25(7-2-12)13-3-8-26-9-4-13/h11-13H,1-10,22H2
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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325566
PNG
(6-Chloro-8-{5-[1-(2-methoxy-ethyl)-piperidin-4-yl]...)
Show SMILES COCCN1CCC(CC1)c1nnc(o1)-c1cc(Cl)c(N)c2CCCOc12
Show InChI InChI=1S/C19H25ClN4O3/c1-25-10-8-24-6-4-12(5-7-24)18-22-23-19(27-18)14-11-15(20)16(21)13-3-2-9-26-17(13)14/h11-12H,2-10,21H2,1H3
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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325567
PNG
(6-Chloro-8-{5-[1-(3-methyl-butyl)-piperidin-4-yl]-...)
Show SMILES CC(C)CCN1CCC(CC1)c1nnc(o1)-c1cc(Cl)c(N)c2CCCOc12
Show InChI InChI=1S/C21H29ClN4O2/c1-13(2)5-8-26-9-6-14(7-10-26)20-24-25-21(28-20)16-12-17(22)18(23)15-4-3-11-27-19(15)16/h12-14H,3-11,23H2,1-2H3
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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325568
PNG
(6-Chloro-8-[5-(1-cyclobutylmethyl-piperidin-4-yl)-...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC3CCC3)CC2)c2OCCCc12
Show InChI InChI=1S/C21H27ClN4O2/c22-17-11-16(19-15(18(17)23)5-2-10-27-19)21-25-24-20(28-21)14-6-8-26(9-7-14)12-13-3-1-4-13/h11,13-14H,1-10,12,23H2
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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325571
PNG
(6-Chloro-8-[5-(1-cyclopropylmethyl-piperidin-4-yl)...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC3CC3)CC2)c2OCCCc12
Show InChI InChI=1S/C20H25ClN4O2/c21-16-10-15(18-14(17(16)22)2-1-9-26-18)20-24-23-19(27-20)13-5-7-25(8-6-13)11-12-3-4-12/h10,12-13H,1-9,11,22H2
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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325572
PNG
(6-Chloro-8-[5-(1-isopropyl-piperidin-4-yl)-[1,3,4]...)
Show SMILES CC(C)N1CCC(CC1)c1nnc(o1)-c1cc(Cl)c(N)c2CCCOc12
Show InChI InChI=1S/C19H25ClN4O2/c1-11(2)24-7-5-12(6-8-24)18-22-23-19(26-18)14-10-15(20)16(21)13-4-3-9-25-17(13)14/h10-12H,3-9,21H2,1-2H3
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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325573
PNG
(6-Chloro-8-{5-[1-(3-methoxy-propyl)-piperidin-4-yl...)
Show SMILES COCCCN1CCC(CC1)c1nnc(o1)-c1cc(Cl)c(N)c2CCCOc12
Show InChI InChI=1S/C20H27ClN4O3/c1-26-10-3-7-25-8-5-13(6-9-25)19-23-24-20(28-19)15-12-16(21)17(22)14-4-2-11-27-18(14)15/h12-13H,2-11,22H2,1H3
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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325574
PNG
(6-Chloro-8-[5-(1-cyclobutyl-piperidin-4-yl)-[1,3,4...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC2)C2CCC2)c2OCCCc12
Show InChI InChI=1S/C20H25ClN4O2/c21-16-11-15(18-14(17(16)22)5-2-10-26-18)20-24-23-19(27-20)12-6-8-25(9-7-12)13-3-1-4-13/h11-13H,1-10,22H2
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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325575
PNG
(6-Chloro-8-[5-(1-cyclobutylmethyl-piperidin-4-yl)-...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC3CCC3)CC2)c2OCCOc12
Show InChI InChI=1S/C20H25ClN4O3/c21-15-10-14(17-18(16(15)22)27-9-8-26-17)20-24-23-19(28-20)13-4-6-25(7-5-13)11-12-2-1-3-12/h10,12-13H,1-9,11,22H2
PDB

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Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325576
PNG
(6-Chloro-8-[5-(1-cyclobutyl-piperidin-4-yl)-[1,3,4...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC2)C2CCC2)c2OCCOc12
Show InChI InChI=1S/C19H23ClN4O3/c20-14-10-13(16-17(15(14)21)26-9-8-25-16)19-23-22-18(27-19)11-4-6-24(7-5-11)12-2-1-3-12/h10-12H,1-9,21H2
PDB

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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325577
PNG
(6-Chloro-8-[5-(1-cyclopentyl-piperidin-4-yl)-[1,3,...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC2)C2CCCC2)c2OCCCc12
Show InChI InChI=1S/C21H27ClN4O2/c22-17-12-16(19-15(18(17)23)6-3-11-27-19)21-25-24-20(28-21)13-7-9-26(10-8-13)14-4-1-2-5-14/h12-14H,1-11,23H2
PDB

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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325578
PNG
(6-Chloro-8-[5-(2-piperidin-1-yl-ethyl)-[1,3,4]oxad...)
Show SMILES Nc1c(Cl)cc(-c2nnc(CCN3CCCCC3)o2)c2OCCCc12
Show InChI InChI=1S/C18H23ClN4O2/c19-14-11-13(17-12(16(14)20)5-4-10-24-17)18-22-21-15(25-18)6-9-23-7-2-1-3-8-23/h11H,1-10,20H2
PDB

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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325579
PNG
(4-[5-(5-Amino-6-chloro-chroman-8-yl)-[1,3,4]oxadia...)
Show SMILES CCOC(=O)N1CCC(CC1)N1CCC(CC1)c1nnc(o1)-c1cc(Cl)c(N)c2CCCOc12
Show InChI InChI=1S/C24H32ClN5O4/c1-2-32-24(31)30-11-7-16(8-12-30)29-9-5-15(6-10-29)22-27-28-23(34-22)18-14-19(25)20(26)17-4-3-13-33-21(17)18/h14-16H,2-13,26H2,1H3
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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325580
PNG
(6-Chloro-8-[5-(3-piperidin-1-yl-propyl)-[1,3,4]oxa...)
Show SMILES Nc1c(Cl)cc(-c2nnc(CCCN3CCCCC3)o2)c2OCCCc12
Show InChI InChI=1S/C19H25ClN4O2/c20-15-12-14(18-13(17(15)21)6-5-11-25-18)19-23-22-16(26-19)7-4-10-24-8-2-1-3-9-24/h12H,1-11,21H2
PDB

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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325581
PNG
(6-Chloro-8-[5-(1-cyclopentyl-piperidin-4-ylmethyl)...)
Show SMILES Nc1c(Cl)cc(-c2nnc(CC3CCN(CC3)C3CCCC3)o2)c2OCCCc12
Show InChI InChI=1S/C22H29ClN4O2/c23-18-13-17(21-16(20(18)24)6-3-11-28-21)22-26-25-19(29-22)12-14-7-9-27(10-8-14)15-4-1-2-5-15/h13-15H,1-12,24H2
PDB

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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325582
PNG
(6-Chloro-8-[5-(3-isopropyl-3-aza-bicyclo[3.1.0]hex...)
Show SMILES CC(C)N1CC2C(C1)C2c1nnc(o1)-c1cc(Cl)c(N)c2CCCOc12
Show InChI InChI=1S/C19H23ClN4O2/c1-9(2)24-7-12-13(8-24)15(12)19-23-22-18(26-19)11-6-14(20)16(21)10-4-3-5-25-17(10)11/h6,9,12-13,15H,3-5,7-8,21H2,1-2H3
PDB

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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325583
PNG
(6-Chloro-8-[5-(3-cyclobutylmethyl-3-aza-bicyclo[3....)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2C3CN(CC4CCC4)CC23)c2OCCCc12
Show InChI InChI=1S/C21H25ClN4O2/c22-16-7-13(19-12(18(16)23)5-2-6-27-19)20-24-25-21(28-20)17-14-9-26(10-15(14)17)8-11-3-1-4-11/h7,11,14-15,17H,1-6,8-10,23H2
PDB

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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325584
PNG
(6-Chloro-8-[5-(3-cyclopropylmethyl-3-aza-bicyclo[3...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2C3CN(CC4CC4)CC23)c2OCCCc12
Show InChI InChI=1S/C20H23ClN4O2/c21-15-6-12(18-11(17(15)22)2-1-5-26-18)19-23-24-20(27-19)16-13-8-25(9-14(13)16)7-10-3-4-10/h6,10,13-14,16H,1-5,7-9,22H2
PDB

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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325585
PNG
(6-Chloro-8-{5-[1-(tetrahydro-pyran-4-yl)-piperidin...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC2)C2CCOCC2)c2OCCCc12
Show InChI InChI=1S/C21H27ClN4O3/c22-17-12-16(19-15(18(17)23)2-1-9-28-19)21-25-24-20(29-21)13-3-7-26(8-4-13)14-5-10-27-11-6-14/h12-14H,1-11,23H2
PDB

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SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325586
PNG
(6-Chloro-8-{5-[1-(tetrahydro-pyran-4-ylmethyl)-pip...)
Show SMILES Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC3CCOCC3)CC2)c2OCCCc12
Show InChI InChI=1S/C22H29ClN4O3/c23-18-12-17(20-16(19(18)24)2-1-9-29-20)22-26-25-21(30-22)15-3-7-27(8-4-15)13-14-5-10-28-11-6-14/h12,14-15H,1-11,13,24H2
PDB

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n/an/an/an/a 18n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325593
PNG
(4-[5-(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-yl...)
Show SMILES CCOC(=O)N1CCC(CC1)N1CCC(CC1)c1nnc(o1)-c1cc(Cl)c(N)c2CCOc12
Show InChI InChI=1S/C23H30ClN5O4/c1-2-31-23(30)29-10-5-15(6-11-29)28-8-3-14(4-9-28)21-26-27-22(33-21)17-13-18(24)19(25)16-7-12-32-20(16)17/h13-15H,2-12,25H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))
BDBM325588
PNG
(5-Chloro-7-[5-(1-cyclobutyl-piperidin-4-yl)-[1,3,4...)
Show SMILES Nc1c2CCOc2c(cc1Cl)-c1nnc(o1)C1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H23ClN4O2/c20-15-10-14(17-13(16(15)21)6-9-25-17)19-23-22-18(26-19)11-4-7-24(8-5-11)12-2-1-3-12/h10-12H,1-9,21H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 10n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...


US Patent US9636335 (2017)


BindingDB Entry DOI: 10.7270/Q2PG1TTQ
More data for this
Ligand-Target Pair