Reaction Details |
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Target | Dipeptidyl peptidase 4 |
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Ligand | BDBM11917 |
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Substrate/Competitor | BDBM11526 |
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Meas. Tech. | In Vitro DPP-IV Inhibition Assays |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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Ki | 52±5 nM |
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Citation | Zhao, G; Taunk, PC; Magnin, DR; Simpkins, LM; Robl, JA; Wang, A; Robertson, JG; Marcinkeviciene, J; Sitkoff, DF; Parker, RA; Kirby, MS; Hamann, LG Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett15:3992-5 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Dipeptidyl peptidase 4 |
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Name: | Dipeptidyl peptidase 4 |
Synonyms: | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_PIG | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | T-cell activation antigen CD26 |
Type: | Enzyme |
Mol. Mass.: | 88235.21 |
Organism: | Sus scrofa (pig) |
Description: | n/a |
Residue: | 766 |
Sequence: | MKTPWKVLLGLLGIAALVTVITVPVVLLNKGTDDAAADSRRTYTLTDYLKSTFRVKFYTL
QWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNL
SSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYL
CGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPA
EPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISN
EHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLY
TLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKY
PLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWE
YYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLS
KALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP
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BDBM11917 |
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BDBM11526 |
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Name | BDBM11917 |
Synonyms: | (1S,3S,5S)-2-[(1S,2S,5R)-3-azabicyclo[3.1.0]hexan-2-ylcarbonyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile | substituted diprolyl nitrile 10 |
Type | Small organic molecule |
Emp. Form. | C12H15N3O |
Mol. Mass. | 217.267 |
SMILES | O=C([C@H]1NC[C@@H]2C[C@H]12)N1[C@H]2C[C@H]2C[C@H]1C#N |r| |
Structure |
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