Reaction Details |
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Target | Trace amine-associated receptor 1 |
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Ligand | BDBM330172 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Radioligand Binding Assay on Mouse |
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IC50 | 277±n/a nM |
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Citation | Cecere, G; Galley, G; Hu, Y; Norcross, R; Pflieger, P; Shen, H 5-oxa-2-azabicyclo[2.2.2]OCTAN-4-yl and 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl derivatives US Patent US9663530 Publication Date 5/30/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Trace amine-associated receptor 1 |
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Name: | Trace amine-associated receptor 1 |
Synonyms: | TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1 |
Type: | Enzyme |
Mol. Mass.: | 38034.73 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q923Y9 |
Residue: | 332 |
Sequence: | MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWL
LHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDR
YYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRG
CFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQ
SKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMV
YAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
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BDBM330172 |
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n/a |
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Name | BDBM330172 |
Synonyms: | 4-Chloro-N-[4-[[(1 S,4S)-5-oxa-2-azabicyclo[2.2.1]heptan-4-yl]methyl]phenyl]-3-propyl-1H-pyrazole-5-carboxamide | US9663530, Example 16 |
Type | Small organic molecule |
Emp. Form. | C19H23ClN4O2 |
Mol. Mass. | 374.865 |
SMILES | CCCc1n[nH]c(C(=O)Nc2ccc(C[C@]34CN[C@H](CO3)C4)cc2)c1Cl |r| |
Structure |
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