| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-A2 [171-432]/Cyclin-dependent kinase 2 [F82H,L83V,H84D] |
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| Ligand | BDBM12082 |
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| Substrate/Competitor | Histone H1 |
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| Meas. Tech. | CDK Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 7300±n/a nM |
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| Citation |  Pratt, DJ; Bentley, J; Jewsbury, P; Boyle, FT; Endicott, JA; Noble, ME Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity. J Med Chem49:5470-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cyclin-A2 [171-432]/Cyclin-dependent kinase 2 [F82H,L83V,H84D] |
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| Name: | Cyclin-A2 [171-432]/Cyclin-dependent kinase 2 [F82H,L83V,H84D] |
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| Synonyms: | Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H/L83V/H84D) |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-A2 [171-432] |
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| Synonyms: | CCN1 | CCNA | CCNA2 | CCNA2_HUMAN | cyclin A2 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 30018.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | cyclin A2 is a c-terminal cyclin A fragment encoding residues 171-432. |
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| Residue: | 262 |
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| Sequence: | SVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNE
TLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQ
VLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKY
LPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIR
EKYKNSKYHGVSLLNPPETLNL
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| Component 2 |
| Name: | Cyclin-dependent kinase 2 [F82H,L83V,H84D] |
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| Synonyms: | CDK2 | CDK2_HUMAN | CDKN2 | Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H/L83V/H84D) |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33891.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941[F82H,L83V,H84D] |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEHVDQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM12082 |
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| Histone H1 |
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| Name: | Histone H1 |
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| Synonyms: | n/a |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 358.43 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 3 |
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| Sequence: | |
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