Reaction Details |
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Target | Proto-oncogene tyrosine-protein kinase Src |
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Ligand | BDBM12241 |
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Substrate/Competitor | poly(E,Y) |
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Meas. Tech. | In Vitro Src Kinase Inhibition Test |
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IC50 | 3±n/a nM |
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Citation | Hennequin, LF; Allen, J; Breed, J; Curwen, J; Fennell, M; Green, TP; Lambert-van der Brempt, C; Morgentin, R; Norman, RA; Olivier, A; Otterbein, L; Ple, PA; Warin, N; Costello, G N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J Med Chem49:6465-88 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Proto-oncogene tyrosine-protein kinase Src |
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Name: | Proto-oncogene tyrosine-protein kinase Src |
Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src |
Type: | Protein |
Mol. Mass.: | 59838.60 |
Organism: | Homo sapiens (Human) |
Description: | P12931 |
Residue: | 536 |
Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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BDBM12241 |
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poly(E,Y) |
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Name: | poly(E,Y) |
Synonyms: | n/a |
Type: | Random Copolymer |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | A poly(Glu,Tyr) 4:1 random copolymer.
10 uM ATP was used as co-substrate |
Residue: | 3 |
Sequence: | |