Reaction Details |
| Report a problem with these data |
Target | Coagulation factor X |
---|
Ligand | BDBM12559 |
---|
Substrate/Competitor | BDBM12500 |
---|
Meas. Tech. | Factor Xa Inhibition Assay |
---|
pH | 7.8±n/a |
---|
Temperature | 298.15±n/a K |
---|
Ki | 10600±n/a nM |
---|
Citation | Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors. Bioorg Med Chem Lett16:3784-8 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Coagulation factor X |
---|
Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
BDBM12559 |
---|
BDBM12500 |
---|
Name | BDBM12559 |
Synonyms: | 6-chloro-N-{1-[2-methyl-1-oxo-1-(piperidin-1-yl)propan-2-yl]-2-oxopyrrolidin-3-yl}naphthalene-2-sulfonamide | pyrrolidin-2-one-based inhibitor 14 |
Type | Small organic molecule |
Emp. Form. | C23H28ClN3O4S |
Mol. Mass. | 478.004 |
SMILES | CC(C)(N1CCC(NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 |
Structure |
|