| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM12590 |
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| Substrate/Competitor | BDBM12583 |
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| Meas. Tech. | Thrombin Assay |
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| pH | 8±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 12000±n/a nM |
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| Citation |  Howard, N; Abell, C; Blakemore, W; Chessari, G; Congreve, M; Howard, S; Jhoti, H; Murray, CW; Seavers, LC; van Montfort, RL Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors. J Med Chem49:1346-55 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM12590 |
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| BDBM12583 |
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| Name | BDBM12590 |
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| Synonyms: | (6-aminoacridin-3-yl)amine | MLS003876812 | Proflavin | Proflavine | SMR002533346 | acridine-3,6-diamine | cid_7099 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11N3 |
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| Mol. Mass. | 209.2465 |
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| SMILES | Nc1ccc2cc3ccc(N)cc3nc2c1 |
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| Structure | 
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