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TargetCoagulation factor VII
LigandBDBM12720
Substrate/CompetitorBDBM12679
Meas. Tech.Enzyme Assay and Determination of the Inhibition Constants.
Ki>15000±n/a nM
Citation Fevig, JMCacciola, JBuriak, JRossi, KAKnabb, RMLuettgen, JMWong, PCBai, SAWexler, RRLam, PY Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa. Bioorg Med Chem Lett16:3755-60 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Coagulation factor VII
Name:Coagulation factor VII
Synonyms:Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:Enzyme
Mol. Mass.:51599.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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  Blast E-value cutoff:
BDBM12720
BDBM12679
NameBDBM12720
Synonyms:6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide | pyrazolo[4,3-d]pyrimidinone 39b
TypeSmall organic molecule
Emp. Form.C30H27FN6O3
Mol. Mass.538.5722
SMILESCOc1ccc(cc1)-n1nc(C(N)=O)c2ncn(-c3ccc(cc3F)-c3ccccc3CN3CCCC3)c(=O)c12
Structure
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