Reaction Details | |||
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Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM50384599 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 550±n/a nM | ||
Citation | Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM50384599 | |||
n/a | |||
Name | BDBM50384599 | ||
Synonyms: | CHEMBL2036790 | US9744172, Compound UNC00000479A | ||
Type | Small organic molecule | ||
Emp. Form. | C18H22FN7 | ||
Mol. Mass. | 355.4126 | ||
SMILES | CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(F)nc1 |(25.93,-29.7,;27.27,-30.47,;28.6,-29.7,;28.6,-28.15,;29.93,-27.38,;31.27,-28.15,;32.74,-27.67,;33.65,-28.92,;32.74,-30.18,;33.22,-31.64,;32.19,-32.79,;30.68,-32.45,;29.65,-33.59,;30.12,-35.06,;29.09,-36.2,;31.63,-35.38,;32.66,-34.24,;31.27,-29.7,;29.93,-30.47,;33.22,-26.2,;32.19,-25.07,;32.66,-23.61,;34.17,-23.28,;34.64,-21.81,;35.2,-24.43,;34.72,-25.89,)| | ||
Structure |