Reaction Details | |||
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Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM50384602 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | <10±n/a nM | ||
Citation | Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM50384602 | |||
n/a | |||
Name | BDBM50384602 | ||
Synonyms: | CHEMBL2036795 | US9744172, Compound UNC00000344A | ||
Type | Small organic molecule | ||
Emp. Form. | C22H30N6 | ||
Mol. Mass. | 378.5138 | ||
SMILES | CCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1 |(18.02,-41.5,;18.01,-43.04,;19.35,-43.81,;19.35,-45.35,;20.68,-46.13,;22.01,-45.36,;22.02,-43.81,;23.35,-43.04,;24.68,-43.81,;26.16,-43.33,;27.07,-44.58,;26.16,-45.84,;26.63,-47.3,;25.6,-48.44,;24.09,-48.11,;23.06,-49.25,;23.53,-50.72,;22.5,-51.86,;25.04,-51.04,;26.08,-49.9,;24.68,-45.36,;23.35,-46.13,;26.63,-41.86,;28.14,-41.54,;28.62,-40.08,;27.58,-38.94,;26.07,-39.26,;25.6,-40.73,)| | ||
Structure |