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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM336383 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM336383 | |||
| n/a | |||
| Name | BDBM336383 | ||
| Synonyms: | US9744172, Compound UNC1059A | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H34N6O3S | ||
| Mol. Mass. | 486.63 | ||
| SMILES | CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC |r,wD:15.15,(-8.08,-3.43,;-6.75,-2.66,;-5.42,-3.43,;-4.08,-2.66,;-2.75,-3.43,;-1.42,-2.66,;-1.42,-1.12,;-.08,-.35,;1.25,-1.12,;2.72,-.64,;3.62,-1.89,;2.72,-3.13,;3.12,-4.62,;4.6,-5.02,;5,-6.51,;3.91,-7.59,;4.31,-9.08,;2.43,-7.2,;2.03,-5.71,;1.25,-2.66,;-.08,-3.43,;3.12,.85,;4.6,1.25,;5,2.73,;3.91,3.82,;2.43,3.42,;2.03,1.94,;4.31,5.31,;5.85,5.31,;2.98,6.08,;4.71,6.8,;6.2,7.2,;6.6,8.68,;8.08,9.08,)| | ||
| Structure | 
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