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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM336407 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM336407 | |||
| n/a | |||
| Name | BDBM336407 | ||
| Synonyms: | US9744172, Compound UNC1084A | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H36FN7O | ||
| Mol. Mass. | 481.6087 | ||
| SMILES | CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1 |r,wU:13.12,wD:16.16,(-8.57,-4.12,;-7.24,-3.35,;-5.91,-4.12,;-4.57,-3.35,;-3.24,-4.12,;-1.91,-3.35,;-1.91,-1.81,;-.57,-1.04,;.76,-1.81,;2.23,-1.33,;3.13,-2.58,;2.23,-3.82,;2.62,-5.31,;4.11,-5.71,;5.2,-4.62,;6.69,-5.02,;7.09,-6.51,;8.57,-6.9,;6,-7.59,;4.51,-7.2,;.76,-3.35,;-.57,-4.12,;2.62,.16,;1.54,1.25,;1.93,2.73,;3.42,3.13,;3.82,4.62,;5.31,5.02,;5.71,6.51,;4.62,7.59,;3.13,7.2,;2.73,5.71,;4.51,2.04,;6,2.44,;4.11,.56,)| | ||
| Structure | 
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