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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM336443 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM336443 | |||
| n/a | |||
| Name | BDBM336443 | ||
| Synonyms: | US9744172, Compound UNC1185A | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H39N7O4S | ||
| Mol. Mass. | 569.719 | ||
| SMILES | CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC(=O)NC1CCCC1 |r,wD:15.15,(-10.07,-4.36,;-8.74,-3.59,;-7.41,-4.36,;-6.07,-3.59,;-4.74,-4.36,;-3.4,-3.59,;-3.4,-2.05,;-2.07,-1.28,;-.74,-2.05,;.73,-1.57,;1.63,-2.82,;.73,-4.06,;1.13,-5.55,;2.61,-5.95,;3.01,-7.44,;1.92,-8.53,;2.32,-10.01,;.44,-8.13,;.04,-6.64,;-.74,-3.59,;-2.07,-4.36,;1.13,-.08,;2.61,.31,;3.01,1.8,;1.92,2.89,;.44,2.49,;.04,1,;2.32,4.38,;.83,4.78,;1.92,5.87,;3.81,4.78,;4.21,6.26,;5.7,6.66,;6.78,5.57,;6.09,8.15,;7.58,8.55,;8.06,10.01,;9.6,10.01,;10.07,8.55,;8.83,7.64,)| | ||
| Structure | 
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