Reaction Details |
| Report a problem with these data |
Target | Nuclear receptor ROR-gamma |
---|
Ligand | BDBM332436 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Biochemical TR-FRET Assay |
---|
IC50 | 15.0±n/a nM |
---|
Citation | Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y 4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof US Patent US9745265 Publication Date 8/29/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Nuclear receptor ROR-gamma |
---|
Name: | Nuclear receptor ROR-gamma |
Synonyms: | Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor |
Type: | PROTEIN |
Mol. Mass.: | 58133.31 |
Organism: | Mus musculus |
Description: | ChEMBL_103664 |
Residue: | 516 |
Sequence: | MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
CNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGS
GPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELG
EPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSR
EEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVL
VRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTA
LVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEK
LQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
|
|
|
BDBM332436 |
---|
n/a |
---|
Name | BDBM332436 |
Synonyms: | 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6- ((2S,6R)-2,6- dimethyl- morpholine-4- carbonyl)-1H- indazol-3-yl)-3- fluorobenzoic acid | US10196354, Example 2B | US9745265, 2B |
Type | Small organic molecule |
Emp. Form. | C29H22ClF4N3O5 |
Mol. Mass. | 603.949 |
SMILES | C[C@H]1CN(C[C@@H](C)O1)C(=O)c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O |
Structure |
|