| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM332511 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical TR-FRET Assay |
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| IC50 | 6.00±n/a nM |
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| Citation |  Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y 4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof US Patent US9745265 Publication Date 8/29/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58133.31 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_103664 |
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| Residue: | 516 |
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| Sequence: | MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
CNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGS
GPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELG
EPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSR
EEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVL
VRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTA
LVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEK
LQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK
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| BDBM332511 |
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| n/a |
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| Name | BDBM332511 |
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| Synonyms: | 4-(5-acetamido-1-(2-chloro-6-(trifluoromethyl)-benzoyl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-3-fluorobenzoic acid (30A) and 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-5-(methylamino)-1H-pyrrolo[2,3-c]pyridin-3-yl)-3-fluorobenzoic acid (30B) | US10196354, Example 30A | US9745265, 30A |
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| Type | Small organic molecule |
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| Emp. Form. | C24H14ClF4N3O4 |
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| Mol. Mass. | 519.832 |
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| SMILES | CC(=O)Nc1cc2c(cn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2cn1)-c1ccc(cc1F)C(O)=O |
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| Structure | 
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