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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nuclear receptor ROR-gamma | ||
| Ligand | BDBM332517 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biochemical TR-FRET Assay | ||
| IC50 | 5.00±n/a nM | ||
| Citation |  Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y 4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof US Patent US9745265 Publication Date 8/29/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nuclear receptor ROR-gamma | |||
| Name: | Nuclear receptor ROR-gamma | ||
| Synonyms: | Nr1f3 | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORG_MOUSE | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 58133.31 | ||
| Organism: | Mus musculus | ||
| Description: | ChEMBL_103664 | ||
| Residue: | 516 | ||
| Sequence: |
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| BDBM332517 | |||
| n/a | |||
| Name | BDBM332517 | ||
| Synonyms: | 4-(1-(2-chloro-6- cyclopropylbenzoyl)-1H- indazol-3-yl)-3,5- difluorobenzoic acid | US10196354, Example 33B | US9745265, 33B | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H15ClF2N2O3 | ||
| Mol. Mass. | 452.837 | ||
| SMILES | OC(=O)c1cc(F)c(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3ccccc23)c(F)c1 |(2.72,7.05,;1.23,6.65,;.14,7.74,;.83,5.16,;-.66,4.77,;-1.06,3.28,;-2.54,2.88,;.03,2.19,;-.36,.7,;.54,-.54,;-.36,-1.79,;.03,-3.28,;-1.06,-4.37,;1.52,-3.68,;2.61,-2.59,;2.21,-1.1,;4.1,-2.99,;4.5,-4.47,;3.41,-5.56,;1.92,-5.16,;.83,-6.25,;-.66,-6.65,;.43,-7.74,;-1.83,-1.31,;-3.16,-2.08,;-4.5,-1.31,;-4.5,.23,;-3.16,1,;-1.83,.23,;1.52,2.59,;2.61,1.5,;1.92,4.08,)| | ||
| Structure | 
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