| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM338466 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 4.00±n/a nM |
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| Citation |  Fauber, B; Gobbi, A; Rene, O; van Niel, MB; Gancia, E; Gaines, S; Ladduwahetty, T; Vesey, D; Ward, S; Winship, P Aryl sultam derivatives as RORc modulators US Patent US9751873 Publication Date 9/5/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM338466 |
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| n/a |
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| Name | BDBM338466 |
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| Synonyms: | (7R)-2-[[2,5-difluoro-4-[4-(1,2,4- triazol-4-yl)-1- piperidyl]phenyl]methyl]-7-phenyl- thiazepane 1,1-dioxide | US9751873, Example 153 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29F2N5O2S |
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| Mol. Mass. | 501.592 |
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| SMILES | Fc1cc(N2CCC(CC2)n2cnnc2)c(F)cc1CN1CCCC[C@H](c2ccccc2)S1(=O)=O |r| |
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| Structure | 
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