Compile Data Set for Download or QSAR

Found 889 hits with Last Name = 'winship' and Initial = 'p'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM338460 ((3S,6R)-2-[[2,5-difluoro-4-[(1R,5S)- 6-(1,2,4-tria...) Show SMILES CC[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1cc(F)c(cc1F)N1C[C@H]2[C@@H](C1)[C@@H]2n1cnnc1 |r| Show InChI InChI=1S/C26H29F2N5O2S/c1-2-19-8-9-25(17-6-4-3-5-7-17)36(34,35)33(19)12-18-10-23(28)24(11-22(18)27)31-13-20-21(14-31)26(20)32-15-29-30-16-32/h3-7,10-11,15-16,19-21,25-26H,2,8-9,12-14H2,1H3/t19-,20-,21+,25+,26+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM338467 ((7R)-2-[[2,5-difluoro-4-[(1R,5S)- 6-(1,2,4-triazol...) Show SMILES Fc1cc(N2C[C@H]3[C@@H](C2)[C@@H]3n2cnnc2)c(F)cc1CN1CCCC[C@H](c2ccccc2)S1(=O)=O |r| Show InChI InChI=1S/C25H27F2N5O2S/c26-21-11-23(30-13-19-20(14-30)25(19)31-15-28-29-16-31)22(27)10-18(21)12-32-9-5-4-8-24(35(32,33)34)17-6-2-1-3-7-17/h1-3,6-7,10-11,15-16,19-20,24-25H,4-5,8-9,12-14H2/t19-,20+,24-,25+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM338462 ((3S,6R)-3-ethyl-2-[[2-fluoro-4- [(1R,5S)-6-(1,2,4-...) Show SMILES CC[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1ccc(cc1F)N1C[C@H]2[C@@H](C1)[C@@H]2n1cnnc1 |r| Show InChI InChI=1S/C26H30FN5O2S/c1-2-20-10-11-25(18-6-4-3-5-7-18)35(33,34)32(20)13-19-8-9-21(12-24(19)27)30-14-22-23(15-30)26(22)31-16-28-29-17-31/h3-9,12,16-17,20,22-23,25-26H,2,10-11,13-15H2,1H3/t20-,22-,23+,25+,26+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM338469 ((7R)-2-[[2-fluoro-4-[(1R,5S)-6- (1,2,4-triazol-4-y...) Show SMILES Fc1cc(ccc1CN1CCCC[C@H](c2ccccc2)S1(=O)=O)N1C[C@H]2[C@@H](C1)[C@@H]2n1cnnc1 |r| Show InChI InChI=1S/C25H28FN5O2S/c26-23-12-20(29-14-21-22(15-29)25(21)30-16-27-28-17-30)10-9-19(23)13-31-11-5-4-8-24(34(31,32)33)18-6-2-1-3-7-18/h1-3,6-7,9-10,12,16-17,21-22,24-25H,4-5,8,11,13-15H2/t21-,22+,24-,25+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497901 (6'-amino-6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-di...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnc(N)c(c1)C#N |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C28H22F2N6/c1-27(2)18-9-10-28(27,23-8-4-7-21(34-23)16-11-15(13-31)26(32)33-14-16)25-17(18)12-22(35-36-25)24-19(29)5-3-6-20(24)30/h3-8,11-12,14,18H,9-10H2,1-2H3,(H2,32,33)/t18-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497661 ((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...) Show SMILES Cc1n[nH]cc1-c1cccc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:20:21:14.13:30,17:16:14.13:30| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497898 (2-amino-5-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1ccnc(n1)-c1cnc(N)c(c1)C#N |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H21F2N7/c1-26(2)17-6-8-27(26,21-7-9-32-25(34-21)15-10-14(12-30)24(31)33-13-15)23-16(17)11-20(35-36-23)22-18(28)4-3-5-19(22)29/h3-5,7,9-11,13,17H,6,8H2,1-2H3,(H2,31,33)/t17-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM338448 (2-[2,5-difluoro-4-[[(3S,6R)-3- methyl-1,1-dioxo-6-...) Show SMILES C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1cc(F)c(cc1F)C(CO)c1ccccc1 |r| Show InChI InChI=1S/C26H27F2NO3S/c1-18-12-13-26(20-10-6-3-7-11-20)33(31,32)29(18)16-21-14-25(28)22(15-24(21)27)23(17-30)19-8-4-2-5-9-19/h2-11,14-15,18,23,26,30H,12-13,16-17H2,1H3/t18-,23?,26+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM338458 ((3S,6R)-2-[[2,5-difluoro-4-[4- (1,2,4-triazol-4-yl...) Show SMILES CC[C@@H](CC[C@H](c1ccccc1)S(=O)=O)NCc1cc(F)c(cc1F)N1CCC(CC1)N(C=N)C=N |r| Show InChI InChI=1S/C26H35F2N5O2S/c1-2-21(8-9-26(36(34)35)19-6-4-3-5-7-19)31-16-20-14-24(28)25(15-23(20)27)32-12-10-22(11-13-32)33(17-29)18-30/h3-7,14-15,17-18,21-22,26,29-31,36H,2,8-13,16H2,1H3/t21-,26+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497518 (3-[4-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1ccnc(n1)-c1cnn(CCC#N)c1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H23F2N7/c1-26(2)18-7-9-27(26,22-8-11-31-25(33-22)16-14-32-36(15-16)12-4-10-30)24-17(18)13-21(34-35-24)23-19(28)5-3-6-20(23)29/h3,5-6,8,11,13-15,18H,4,7,9,12H2,1-2H3/t18-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497573 ((2S)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...) Show SMILES C[C@@H](O)Cn1cc(cn1)-c1cccc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:23:24:17.16:33,20:19:17.16:33| Show InChI InChI=1S/C28H27F2N5O/c1-16(36)14-35-15-17(13-31-35)22-8-5-9-24(32-22)28-11-10-19(27(28,2)3)18-12-23(33-34-26(18)28)25-20(29)6-4-7-21(25)30/h4-9,12-13,15-16,19,36H,10-11,14H2,1-3H3/t16-,19+,28+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497648 (N-[[5-[6-[(1R,8R)-5-(2,6-difluorophenyl)- 11,11-di...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-c1ccc(CNS(C)(=O)=O)nc1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C28H26F2N6O2S/c1-27(2)19-9-10-28(27,26-18(19)11-22(35-36-26)25-20(29)5-4-6-21(25)30)24-15-31-14-23(34-24)16-7-8-17(32-12-16)13-33-39(3,37)38/h4-8,11-12,14-15,19,33H,9-10,13H2,1-3H3/t19-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497855 ((5R,8S)-8-(6-(3-(difluoromethyl)-1H- 1,2,4-triazol...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-n1cnc(n1)C(F)F |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C25H20F4N6/c1-24(2)14-9-10-25(24,18-7-4-8-19(31-18)35-12-30-23(34-35)22(28)29)21-13(14)11-17(32-33-21)20-15(26)5-3-6-16(20)27/h3-8,11-12,14,22H,9-10H2,1-2H3/t14-,25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497574 ((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnn(CCS(C)(=O)=O)c1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C28H27F2N5O2S/c1-27(2)19-10-11-28(27,26-18(19)14-23(33-34-26)25-20(29)6-4-7-21(25)30)24-9-5-8-22(32-24)17-15-31-35(16-17)12-13-38(3,36)37/h4-9,14-16,19H,10-13H2,1-3H3/t19-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497658 (2-[4-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnn(CC(N)=O)c1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H24F2N6O/c1-26(2)17-9-10-27(26,22-8-4-7-20(32-22)15-12-31-35(13-15)14-23(30)36)25-16(17)11-21(33-34-25)24-18(28)5-3-6-19(24)29/h3-8,11-13,17H,9-10,14H2,1-2H3,(H2,30,36)/t17-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497586 (3-[4-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnn(CCC#N)c1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C28H24F2N6/c1-27(2)19-10-11-28(27,24-9-4-8-22(33-24)17-15-32-36(16-17)13-5-12-31)26-18(19)14-23(34-35-26)25-20(29)6-3-7-21(25)30/h3-4,6-9,14-16,19H,5,10-11,13H2,1-2H3/t19-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497527 (2-methyl-2-[2-[6-[(1S,8R)-5-(2,6- difluorophenyl)-...) Show SMILES CC(C)(C#N)c1coc(n1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:24:25:18.17:34,21:20:18.17:34| Show InChI InChI=1S/C28H24F2N6O/c1-26(2,14-31)22-13-37-25(34-22)20-11-32-12-21(33-20)28-9-8-16(27(28,3)4)15-10-19(35-36-24(15)28)23-17(29)6-5-7-18(23)30/h5-7,10-13,16H,8-9H2,1-4H3/t16-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497572 ((2R)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...) Show SMILES C[C@H](O)Cn1cc(cn1)-c1cccc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:23:24:17.16:33,20:19:17.16:33| Show InChI InChI=1S/C28H27F2N5O/c1-16(36)14-35-15-17(13-31-35)22-8-5-9-24(32-22)28-11-10-19(27(28,2)3)18-12-23(33-34-26(18)28)25-20(29)6-4-7-21(25)30/h4-9,12-13,15-16,19,36H,10-11,14H2,1-3H3/t16-,19-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497726 ((2R)-1-[[5-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,...) Show SMILES C[C@H](O)CNc1ncc(cn1)-c1cccc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:25:26:19.18:35,22:21:19.18:35| Show InChI InChI=1S/C29H28F2N6O/c1-16(38)13-32-27-33-14-17(15-34-27)22-8-5-9-24(35-22)29-11-10-19(28(29,2)3)18-12-23(36-37-26(18)29)25-20(30)6-4-7-21(25)31/h4-9,12,14-16,19,38H,10-11,13H2,1-3H3,(H,32,33,34)/t16-,19-,29-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM50132477 (CHEMBL3632716 | US9751873, Example 127) Show SMILES C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1cc(F)c(cc1F)C(CO)CC1COC1 |r| Show InChI InChI=1S/C24H29F2NO4S/c1-16-7-8-24(18-5-3-2-4-6-18)32(29,30)27(16)12-19-10-23(26)21(11-22(19)25)20(13-28)9-17-14-31-15-17/h2-6,10-11,16-17,20,24,28H,7-9,12-15H2,1H3/t16-,20?,24+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM338466 ((7R)-2-[[2,5-difluoro-4-[4-(1,2,4- triazol-4-yl)-1...) Show SMILES Fc1cc(N2CCC(CC2)n2cnnc2)c(F)cc1CN1CCCC[C@H](c2ccccc2)S1(=O)=O |r| Show InChI InChI=1S/C25H29F2N5O2S/c26-22-15-24(30-12-9-21(10-13-30)31-17-28-29-18-31)23(27)14-20(22)16-32-11-5-4-8-25(35(32,33)34)19-6-2-1-3-7-19/h1-3,6-7,14-15,17-18,21,25H,4-5,8-13,16H2/t25-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497519 ((2R)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...) Show SMILES C[C@H](O)Cn1cc(cn1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:23:24:17.16:33,20:19:17.16:33| Show InChI InChI=1S/C27H26F2N6O/c1-15(36)13-35-14-16(10-31-35)22-11-30-12-23(32-22)27-8-7-18(26(27,2)3)17-9-21(33-34-25(17)27)24-19(28)5-4-6-20(24)29/h4-6,9-12,14-15,18,36H,7-8,13H2,1-3H3/t15-,18-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497662 ((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-c1cnn(CS(C)(=O)=O)c1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C26H24F2N6O2S/c1-25(2)17-7-8-26(25,24-16(17)9-20(32-33-24)23-18(27)5-4-6-19(23)28)22-12-29-11-21(31-22)15-10-30-34(13-15)14-37(3,35)36/h4-6,9-13,17H,7-8,14H2,1-3H3/t17-,26-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497554 ((1S,8R)-5-(2,6-difluorophenyl)-1-[6-[1-(2- ethylsu...) Show SMILES CCS(=O)(=O)CCn1cc(cn1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:26:27:20.19:36,23:22:20.19:36| Show InChI InChI=1S/C28H28F2N6O2S/c1-4-39(37,38)11-10-36-16-17(13-32-36)23-14-31-15-24(33-23)28-9-8-19(27(28,2)3)18-12-22(34-35-26(18)28)25-20(29)6-5-7-21(25)30/h5-7,12-16,19H,4,8-11H2,1-3H3/t19-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497655 (N-[5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnc(NS(C)(=O)=O)nc1 |r,TLB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H24F2N6O2S/c1-26(2)17-10-11-27(26,24-16(17)12-21(33-34-24)23-18(28)6-4-7-19(23)29)22-9-5-8-20(32-22)15-13-30-25(31-14-15)35-38(3,36)37/h4-9,12-14,17H,10-11H2,1-3H3,(H,30,31,35)/t17-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497657 ((2R)-2-methyl-3-[4-[6-[(1S,8R)-5-(2,6- difluorophe...) Show SMILES C[C@@H](Cn1cc(cn1)-c1cccc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C)C(N)=O |r,TLB:22:23:16.15:32,19:18:16.15:32| Show InChI InChI=1S/C29H28F2N6O/c1-16(27(32)38)14-37-15-17(13-33-37)22-8-5-9-24(34-22)29-11-10-19(28(29,2)3)18-12-23(35-36-26(18)29)25-20(30)6-4-7-21(25)31/h4-9,12-13,15-16,19H,10-11,14H2,1-3H3,(H2,32,38)/t16-,19-,29-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497656 ((2S)-2-methyl-3-[4-[6-[(1S,8R)-5-(2,6- difluorophe...) Show SMILES C[C@H](Cn1cc(cn1)-c1cccc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C)C(N)=O |r,TLB:22:23:16.15:32,19:18:16.15:32| Show InChI InChI=1S/C29H28F2N6O/c1-16(27(32)38)14-37-15-17(13-33-37)22-8-5-9-24(34-22)29-11-10-19(28(29,2)3)18-12-23(35-36-26(18)29)25-20(30)6-4-7-21(25)31/h4-9,12-13,15-16,19H,10-11,14H2,1-3H3,(H2,32,38)/t16-,19+,29+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497559 ((2S)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...) Show SMILES CC[C@@H](O)Cn1cc(cn1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:24:25:18.17:34,21:20:18.17:34| Show InChI InChI=1S/C28H28F2N6O/c1-4-17(37)15-36-14-16(11-32-36)23-12-31-13-24(33-23)28-9-8-19(27(28,2)3)18-10-22(34-35-26(18)28)25-20(29)6-5-7-21(25)30/h5-7,10-14,17,19,37H,4,8-9,15H2,1-3H3/t17-,19+,28+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497561 ((2R)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...) Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:24:25:18.17:34,21:20:18.17:34| Show InChI InChI=1S/C28H28F2N6O/c1-4-17(37)15-36-14-16(11-32-36)23-12-31-13-24(33-23)28-9-8-19(27(28,2)3)18-10-22(34-35-26(18)28)25-20(29)6-5-7-21(25)30/h5-7,10-14,17,19,37H,4,8-9,15H2,1-3H3/t17-,19-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497587 (2-[3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,11-...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnn(c1)C1(CC#N)COC1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C30H26F2N6O/c1-28(2)20-9-10-30(28,27-19(20)13-24(36-37-27)26-21(31)5-3-6-22(26)32)25-8-4-7-23(35-25)18-14-34-38(15-18)29(11-12-33)16-39-17-29/h3-8,13-15,20H,9-11,16-17H2,1-2H3/t20-,30-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497562 ((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-c1ccn(CCS(C)(=O)=O)n1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H26F2N6O2S/c1-26(2)17-7-9-27(26,25-16(17)13-21(32-33-25)24-18(28)5-4-6-19(24)29)23-15-30-14-22(31-23)20-8-10-35(34-20)11-12-38(3,36)37/h4-6,8,10,13-15,17H,7,9,11-12H2,1-3H3/t17-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497893 (N-[6-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1ccc(NS(C)(=O)=O)nn1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H24F2N6O2S/c1-26(2)16-12-13-27(26,25-15(16)14-21(32-34-25)24-17(28)6-4-7-18(24)29)22-9-5-8-19(30-22)20-10-11-23(33-31-20)35-38(3,36)37/h4-11,14,16H,12-13H2,1-3H3,(H,33,35)/t16-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497730 ((2S)-3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnn(C[C@H](O)C(N)=O)c1 |r,TLB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C28H26F2N6O2/c1-27(2)17-9-10-28(27,25-16(17)11-21(34-35-25)24-18(29)5-3-6-19(24)30)23-8-4-7-20(33-23)15-12-32-36(13-15)14-22(37)26(31)38/h3-8,11-13,17,22,37H,9-10,14H2,1-2H3,(H2,31,38)/t17-,22-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497869 (5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dimeth...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnc(nc1)C(O)=O |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H21F2N5O2/c1-26(2)16-9-10-27(26,21-8-4-7-19(32-21)14-12-30-24(25(35)36)31-13-14)23-15(16)11-20(33-34-23)22-17(28)5-3-6-18(22)29/h3-8,11-13,16H,9-10H2,1-2H3,(H,35,36)/t16-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM338335 ((1R,5S,6S)-3-[2,5-Difluoro-4- ((3S,6R)-3-methyl-1,...) Show SMILES C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1cc(F)c(cc1F)N1C[C@H]2[C@@H](C1)C2n1cnnc1 |r| Show InChI InChI=1S/C25H27F2N5O2S/c1-16-7-8-24(17-5-3-2-4-6-17)35(33,34)32(16)11-18-9-22(27)23(10-21(18)26)30-12-19-20(13-30)25(19)31-14-28-29-15-31/h2-6,9-10,14-16,19-20,24-25H,7-8,11-13H2,1H3/t16-,19-,20+,24+,25?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM50132478 (CHEMBL3634609 | US9751873, Example 157) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2n1cnnc1)c1cc(F)c(CN2CCCC[C@@H](c3ccccc3)S2(=O)=O)cc1F |r| Show InChI InChI=1S/C25H27F2N5O2S/c26-21-11-23(30-13-19-20(14-30)25(19)31-15-28-29-16-31)22(27)10-18(21)12-32-9-5-4-8-24(35(32,33)34)17-6-2-1-3-7-17/h1-3,6-7,10-11,15-16,19-20,24-25H,4-5,8-9,12-14H2/t19-,20+,24-,25+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM50132478 (CHEMBL3634609 | US9751873, Example 157) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2n1cnnc1)c1cc(F)c(CN2CCCC[C@@H](c3ccccc3)S2(=O)=O)cc1F |r| Show InChI InChI=1S/C25H27F2N5O2S/c26-21-11-23(30-13-19-20(14-30)25(19)31-15-28-29-16-31)22(27)10-18(21)12-32-9-5-4-8-24(35(32,33)34)17-6-2-1-3-7-17/h1-3,6-7,10-11,15-16,19-20,24-25H,4-5,8-9,12-14H2/t19-,20+,24-,25+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...				US Patent US9751873 (2017) BindingDB Entry DOI: 10.7270/Q2BC41NZ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497553 (2-[[5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-di...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-c1ccc(NCCO)nc1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C28H26F2N6O/c1-27(2)18-8-9-28(27,26-17(18)12-21(35-36-26)25-19(29)4-3-5-20(25)30)23-15-31-14-22(34-23)16-6-7-24(33-13-16)32-10-11-37/h3-7,12-15,18,37H,8-11H2,1-2H3,(H,32,33)/t18-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497627 ((2R)-3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-c1cnn(C[C@H](O)CO)c1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H26F2N6O2/c1-26(2)18-6-7-27(26,25-17(18)8-21(33-34-25)24-19(28)4-3-5-20(24)29)23-11-30-10-22(32-23)15-9-31-35(12-15)13-16(37)14-36/h3-5,8-12,16,18,36-37H,6-7,13-14H2,1-2H3/t16-,18-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497703 (N-[[1-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-di...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-n1ccc(CNS(C)(=O)=O)n1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C26H25F2N7O2S/c1-25(2)17-7-9-26(25,24-16(17)11-20(32-33-24)23-18(27)5-4-6-19(23)28)21-13-29-14-22(31-21)35-10-8-15(34-35)12-30-38(3,36)37/h4-6,8,10-11,13-14,17,30H,7,9,12H2,1-3H3/t17-,26-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497645 (3-[4-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-c1cnn(CCC(N)=O)c1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H25F2N7O/c1-26(2)17-6-8-27(26,25-16(17)10-20(34-35-25)24-18(28)4-3-5-19(24)29)22-13-31-12-21(33-22)15-11-32-36(14-15)9-7-23(30)37/h3-5,10-14,17H,6-9H2,1-2H3,(H2,30,37)/t17-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497511 ((1S)-2-methyl-1-[2-[6-[(1R,8R)-5-(2,6- difluorophe...) Show SMILES CC(C)[C@@H](O)c1coc(n1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:24:25:18.17:34,21:20:18.17:34| Show InChI InChI=1S/C28H27F2N5O2/c1-14(2)24(36)21-13-37-26(33-21)20-11-31-12-22(32-20)28-9-8-16(27(28,3)4)15-10-19(34-35-25(15)28)23-17(29)6-5-7-18(23)30/h5-7,10-14,16,24,36H,8-9H2,1-4H3/t16-,24+,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497520 ((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-c1cnn(CCS(C)(=O)=O)c1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C27H26F2N6O2S/c1-26(2)18-7-8-27(26,25-17(18)11-21(33-34-25)24-19(28)5-4-6-20(24)29)23-14-30-13-22(32-23)16-12-31-35(15-16)9-10-38(3,36)37/h4-6,11-15,18H,7-10H2,1-3H3/t18-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497894 (3-[5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnc(nc1)C1(O)COC1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C29H25F2N5O2/c1-27(2)18-9-10-29(27,25-17(18)11-22(35-36-25)24-19(30)5-3-6-20(24)31)23-8-4-7-21(34-23)16-12-32-26(33-13-16)28(37)14-38-15-28/h3-8,11-13,18,37H,9-10,14-15H2,1-2H3/t18-,29-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497729 ((2R)-3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnn(C[C@@H](O)C(N)=O)c1 |r,TLB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C28H26F2N6O2/c1-27(2)17-9-10-28(27,25-16(17)11-21(34-35-25)24-18(29)5-3-6-19(24)30)23-8-4-7-20(33-23)15-12-32-36(13-15)14-22(37)26(31)38/h3-8,11-13,17,22,37H,9-10,14H2,1-2H3,(H2,31,38)/t17-,22+,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497659 (N-(2-hydroxyethyl)-2-[4-[6-[(1S,8R)-5- (2,6-difluo...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnn(CC(=O)NCCO)c1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C29H28F2N6O2/c1-28(2)19-9-10-29(28,27-18(19)13-23(35-36-27)26-20(30)5-3-6-21(26)31)24-8-4-7-22(34-24)17-14-33-37(15-17)16-25(39)32-11-12-38/h3-8,13-15,19,38H,9-12,16H2,1-2H3,(H,32,39)/t19-,29-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497647 ((2S)-2-hydroxy-N-[5-[6-[(1S,8R)-5-(2,6- difluoroph...) Show SMILES C[C@H](O)C(=O)Nc1ccc(cn1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:26:27:20.19:36,23:22:20.19:36| Show InChI InChI=1S/C29H26F2N6O2/c1-15(38)27(39)35-24-8-7-16(12-33-24)22-13-32-14-23(34-22)29-10-9-18(28(29,2)3)17-11-21(36-37-26(17)29)25-19(30)5-4-6-20(25)31/h4-8,11-15,18,38H,9-10H2,1-3H3,(H,33,35,39)/t15-,18-,29-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497715 (2-[[5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-di...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cccc(n1)-c1cnc(NCC(N)=O)nc1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C28H25F2N7O/c1-27(2)17-9-10-28(27,25-16(17)11-21(36-37-25)24-18(29)5-3-6-19(24)30)22-8-4-7-20(35-22)15-12-32-26(33-13-15)34-14-23(31)38/h3-8,11-13,17H,9-10,14H2,1-2H3,(H2,31,38)(H,32,33,34)/t17-,28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497552 (2,2,2-trifluoro-N-[(1R)-1-[2-[6-[(1S,8R)-5- (2,6-d...) Show SMILES C[C@@H](NCC(F)(F)F)c1coc(n1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C |r,TLB:27:28:21.20:37,24:23:21.20:37| Show InChI InChI=1S/C28H25F5N6O/c1-14(35-13-28(31,32)33)21-12-40-25(37-21)20-10-34-11-22(36-20)27-8-7-16(26(27,2)3)15-9-19(38-39-24(15)27)23-17(29)5-4-6-18(23)30/h4-6,9-12,14,16,35H,7-8,13H2,1-3H3/t14-,16+,27+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM497664 ((2S)-3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...) Show SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1cncc(n1)-c1cnn(C[C@@H](O)CO)n1 |r,THB:8:7:4.5:1,11:12:4.5:1| Show InChI InChI=1S/C26H25F2N7O2/c1-25(2)16-6-7-26(25,24-15(16)8-19(32-33-24)23-17(27)4-3-5-18(23)28)22-11-29-9-20(31-22)21-10-30-35(34-21)12-14(37)13-36/h3-5,8-11,14,16,36-37H,6-7,12-13H2,1-2H3/t14-,16+,26+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description 50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...				US Patent US11008312 (2021) BindingDB Entry DOI: 10.7270/Q24M97NW
					More data for this Ligand-Target Pair

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