Reaction Details |
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Target | Urokinase-type plasminogen activator [179-431,I214M,N322A,S371A] |
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Ligand | BDBM14142 |
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Substrate/Competitor | BDBM14484 |
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Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants |
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Ki | 380±n/a nM |
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Citation | Katz, BA; Luong, C; Ho, JD; Somoza, JR; Gjerstad, E; Tang, J; Williams, SR; Verner, E; Mackman, RL; Young, WB; Sprengeler, PA; Chan, H; Mortara, K; Janc, JW; McGrath, ME Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J Mol Biol344:527-47 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Urokinase-type plasminogen activator [179-431,I214M,N322A,S371A] |
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Name: | Urokinase-type plasminogen activator [179-431,I214M,N322A,S371A] |
Synonyms: | LMW uPA | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase (uPA) Mutant (S190A) | deglycosylated (N145A) LMW uPA Mutant S190A |
Type: | Enzyme |
Mol. Mass.: | 28389.65 |
Organism: | Homo sapiens (Human) |
Description: | Mutagenically deglycosylated (N145A) low molecular mass urokinase (S190A), referred to as Ala190 uPA. |
Residue: | 253 |
Sequence: | IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVY
LGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTI
CLPSMYNDPQFGTSCEITGFGKEASTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTK
MLCAADPQWKTDACQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPW
IRSHTKEENGLAL
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BDBM14142 |
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BDBM14484 |
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Name | BDBM14142 |
Synonyms: | 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phenylbenzen-1-olate | 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1-BIPHENYL-2-OLATE) | APC-8696 | CA-04 | CRA-8696 |
Type | Small organic molecule |
Emp. Form. | C21H17N3O |
Mol. Mass. | 327.3792 |
SMILES | NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cccc(-c2ccccc2)c1[O-] |
Structure |
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