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TargetSerine protease hepsin
LigandBDBM14482
Substrate/CompetitorBDBM13573
Meas. Tech.Enzyme Assay and Determination of the Inhibition Constants
Ki 2100±n/a nM
Citation Katz, BALuong, CHo, JDSomoza, JRGjerstad, ETang, JWilliams, SRVerner, EMackman, RLYoung, WBSprengeler, PAChan, HMortara, KJanc, JWMcGrath, ME Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J Mol Biol344:527-47 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Serine protease hepsin
Name:Serine protease hepsin
Synonyms:HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1
Type:Enzyme
Mol. Mass.:45016.98
Organism:Homo sapiens (Human)
Description:Human deglycosylated hepsin was expressed in Pichia pastoris.
Residue:417
Sequence:
MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
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  Blast E-value cutoff:
BDBM14482
BDBM13573
NameBDBM14482
Synonyms:2-amino-5-[(3-hydroxynaphthalene-2-)amido]-1H-1,3-benzodiazol-3-ium | CA-24
TypeSmall organic molecule
Emp. Form.C18H15N4O2
Mol. Mass.319.3368
SMILESNc1[nH]c2ccc(NC(=O)c3cc4ccccc4cc3O)cc2[nH+]1
Structure
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