| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [387-1112] |
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| Ligand | BDBM15337 |
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| Substrate/Competitor | BDBM10851 |
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| Meas. Tech. | PDE SPA Enzyme Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 0.11±n/a nM |
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| Citation |  Edmondson, SD; Mastracchio, A; He, J; Chung, CC; Forrest, MJ; Hofsess, S; MacIntyre, E; Metzger, J; O'Connor, N; Patel, K; Tong, X; Tota, MR; Van der Ploeg, LH; Varnerin, JP; Fisher, MH; Wyvratt, MJ; Weber, AE; Parmee, ER Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors. Bioorg Med Chem Lett13:3983-7 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [387-1112] |
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| Name: | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [387-1112] |
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| Synonyms: | CGI-PDE B | CGIP1 | CGIPDE1 | Cyclic GMP-inhibited phosphodiesterase B | PDE3B | PDE3B_HUMAN | Phosphodiesterase Type 3 (PDE3B) | cGMP-inhibited 3',5'-cyclic phosphodiesterase B [387-1112] | cGMP-inhibited 3,5-cyclic phosphodiesterase B |
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| Type: | Enzyme |
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| Mol. Mass.: | 81944.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PDE3B (387-1112) was expressed as soluble proteins in Escherichia coli. |
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| Residue: | 726 |
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| Sequence: | MGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSG
LLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRR
AGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQ
QLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETE
KKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVE
KMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVL
HAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNI
PALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRP
EYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRL
LVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAK
LQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNP
KPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQADEIQVIE
EADEEE
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| BDBM15337 |
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| BDBM10851 |
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| Name | BDBM15337 |
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| Synonyms: | (5R)-6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one | (5R)-6-[4-({2-[(3-iodophenyl)methyl]-3-oxocyclohex-1-en-1-yl}amino)phenyl]-5-methyl-2,3,4,5-tetrahydropyridazin-3-one | MERCK1 | dihydropyridazinone 14e |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24IN3O2 |
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| Mol. Mass. | 513.3707 |
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| SMILES | C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1 |r,c:6,14| |
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| Structure | 
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