Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 1 [194-712]

Ligand

BDBM347982

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Assay

IC50

<100±n/a nM

Citation

Jorand-Lebrun, C; Jones, R; Won, AC; Nguyen, N; Johnson, TL; Deselm, LC; Panda, K Heteroaryl compounds as IRAK inhibitors and uses thereof US Patent US9790221 Publication Date 10/17/2017

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 1 [194-712]

Name:

Interleukin-1 receptor-associated kinase 1 [194-712]

Synonyms:

IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

55943.99

Organism:

Homo sapiens (Human)

Description:

aa 194-712

Residue:

519

Sequence:

RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK
QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP
QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS
QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKY
LKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGL
GQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGR
AHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPA
PLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKL
ALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS

BDBM347982

n/a

Name

BDBM347982

Synonyms:

US9790221, Compound 188

Type

Small organic molecule

Emp. Form.

C23H26N8

Mol. Mass.

414.5061

SMILES

Cn1cc(cn1)-c1cccc(c1)-c1ncc(-c2cnn(C)c2)c(NC2CC(CN)C2)n1 |(2.91,5.84,;1.43,6.23,;.52,4.99,;-.94,5.46,;-.94,7,;.52,7.48,;-2.28,4.69,;-3.61,5.46,;-4.94,4.69,;-4.94,3.15,;-3.61,2.38,;-2.28,3.15,;-3.61,.84,;-4.94,.07,;-4.94,-1.47,;-3.61,-2.24,;-3.61,-3.78,;-4.86,-4.68,;-4.38,-6.15,;-2.84,-6.15,;-2.07,-7.48,;-2.36,-4.68,;-2.28,-1.47,;-.94,-2.24,;.39,-1.47,;1.88,-1.86,;2.28,-.38,;3.61,.39,;4.94,-.38,;.79,.02,;-2.28,.07,)|

Structure